Evidence map›Paper›PMID 33670346›Full record

ArticleCancers2021

Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting

Helen R Davies, Kevin D Broad, Zerrin Onadim, Elizabeth A Price, Xueqing Zou, Ibrahim Sheriff, Esin Kotiloğlu Karaa, Irene Scheimberg, M Ashwin Reddy, Mandeep S Sagoo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  10. Mutational analysis of theFrontiers in medicine · 2024
    Article
  11. Cancers · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Helen R DaviesAcademic Department of Medical Genetics, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Kevin D BroadInstitute of Ophthalmology, University College London, London EC1V 9EL, UK.
Zerrin OnadimRetinoblastoma Genetic Screening Unit, The Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK.ORCID 0000-0002-8594-9586
Elizabeth A PriceRetinoblastoma Genetic Screening Unit, The Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK.
Xueqing ZouAcademic Department of Medical Genetics, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Ibrahim SheriffRetinoblastoma Service, Royal London Hospital, Barts Health Trust, London E1 1FR, UK.
Esin Kotiloğlu KaraaPathology Department, Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK.
Irene ScheimbergPathology Department, Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK.
M Ashwin ReddyRetinoblastoma Service, Royal London Hospital, Barts Health Trust, London E1 1FR, UK.
Mandeep S SagooInstitute of Ophthalmology, University College London, London EC1V 9EL, UK.ORCID 0000-0003-1530-3824
Shin-Ichi OhnumaInstitute of Ophthalmology, University College London, London EC1V 9EL, UK.
Serena Nik-ZainalAcademic Department of Medical Genetics, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.ORCID 0000-0001-5054-1727
Barts Health NHS Trust · GBUniversity of Cambridge · GBMoorfields Eye Hospital NHS Foundation Trust · GBUniversity College London · GB

Funding

Cancer Research UK 23916Cancer Research UK C60100/A23916Cancer Research UK C60100/A25274Wellcome Trust
6 · The paper itself

Abstract

The development of retinoblastoma is thought to require pathological genetic changes in both alleles of the

Indexed as

mutational signatureretinoblastomastructural rearrangementwhole-genome sequencing

Identifiers

PMID33670346
PMCPMC7918943
OpenAlexW3128677718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.