Evidence map›Paper›PMID 33670308›Full record

ArticleMarine drugs2021

A New

Catherine R Back, Henry L Stennett, Sam E Williams, Luoyi Wang, Jorge Ojeda Gomez, Omar M Abdulle, Thomas Duffy, Christopher Neal, Judith Mantell, Mark A Jepson and 7 more

Erratum issuedAbstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
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  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Correction: Back et al. A NewMarine drugs · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Catherine R BackSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK.ORCID 0000-0002-9835-9171
Henry L StennettSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK.ORCID 0000-0001-6555-1872
Sam E WilliamsSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK.ORCID 0000-0002-6949-426X
Luoyi WangSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.ORCID 0000-0003-2032-7206
Jorge Ojeda GomezSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Omar M AbdulleSummit Therapeutics, Merrifield Centre, Rosemary Lane, Cambridge CB1 3LQ, UK.
Thomas DuffySummit Therapeutics, Merrifield Centre, Rosemary Lane, Cambridge CB1 3LQ, UK.
Christopher NealWoolfson Bioimaging Facility, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Judith MantellWoolfson Bioimaging Facility, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Mark A JepsonWoolfson Bioimaging Facility, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Katharine R HendrySchool of Earth Sciences, University of Bristol, Wills Memorial Building, Queens Road, Bristol BS8 1RJ, UK.ORCID 0000-0002-0790-5895
David PowellSummit Therapeutics, Merrifield Centre, Rosemary Lane, Cambridge CB1 3LQ, UK.
James E M StachSchool of Natural and Environmental Sciences, Newcastle University, King's Road, Newcastle upon Tyne NE1 7RU, UK.ORCID 0000-0001-8787-2407
Angela E Essex-LoprestiDefence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Christine L WillisSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Paul CurnowSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Paul R RaceSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK.ORCID 0000-0003-0184-5630

Funding

Biotechnology and Biological Sciences Research Council BB/L01386X/1Biotechnology and Biological Sciences Research Council BB/M025624/1Biotechnology and Biological Sciences Research Council BB/T001968/1Engineering and Physical Sciences Research Council EP/L016494/1European Research Council 278705Medical Research Council MR/N0137941/1
6 · The paper itself

Abstract

To tackle the growing problem of antibiotic resistance, it is essential to identify new bioactive compounds that are effective against resistant microbes and safe to use. Natural products and their derivatives are, and will continue to be, an important source of these molecules. Sea sponges harbour a diverse microbiome that co-exists with the sponge, and these bacterial communities produce a rich array of bioactive metabolites for protection and resource competition. For these reasons, the sponge microbiota constitutes a potential source of clinically relevant natural products. To date, efforts in bioprospecting for these compounds have focused predominantly on sponge specimens isolated from shallow water, with much still to be learned about samples from the deep sea. Here we report the isolation of a new

Indexed as

MicrobiotaAnimalsAnti-Bacterial AgentsAntineoplastic AgentsAtlantic OceanBiological ProductsMicromonosporaPoriferaWhole Genome SequencingAnti-Bacterial AgentsAntineoplastic AgentsBiological Productsantibioticbioprospectingbiosynthetic gene clustersdeep seagenome miningnanopore sequencingnatural productsea spongesecondary metabolites

Identifiers

PMID33670308
PMCPMC7918784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.