Evidence map›Paper›PMID 33670307›Full record

ArticleCells2021

Functional and Structural Characterization of ClC-1 and Na

Oscar Brenes, Raffaella Barbieri, Melissa Vásquez, Rebeca Vindas-Smith, Jeffrey Roig, Adarli Romero, Gerardo Del Valle, Luis Bermúdez-Guzmán, Sara Bertelli, Michael Pusch and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Oscar BrenesDepartamento de Fisiología, Escuela de Medicina, Universidad de Costa Rica, 11501 San José, Costa Rica.ORCID 0000-0003-3830-9364
Raffaella BarbieriIstituto di Biofisica, CNR, 16149 Genova, Italy.ORCID 0000-0001-8254-9758
Melissa VásquezInstituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, 11501 San José, Costa Rica.ORCID 0000-0002-8879-5500
Rebeca Vindas-SmithInstituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, 11501 San José, Costa Rica.ORCID 0000-0001-6913-0805
Jeffrey RoigInstituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, 11501 San José, Costa Rica.
Adarli RomeroEscuela de Biología, Universidad de Costa Rica, 11501 San José, Costa Rica.ORCID 0000-0002-5412-3319
Gerardo Del ValleLaboratorio de Neurofisiología (Neurolab), 11801 San José, Costa Rica.
Luis Bermúdez-GuzmánSección de Genética y Biotecnología, Escuela de Biología, Universidad de Costa Rica, 11501 San José, Costa Rica.ORCID 0000-0002-0749-4010
Sara BertelliIstituto di Biofisica, CNR, 16149 Genova, Italy.ORCID 0000-0002-8662-7482
Michael PuschIstituto di Biofisica, CNR, 16149 Genova, Italy.ORCID 0000-0002-8644-8847
Fernando MoralesInstituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, 11501 San José, Costa Rica.ORCID 0000-0002-6564-8671
Universidad de Costa Rica · CRInstituto di Biofisica · ESScuola Internazionale Superiore di Studi Avanzati · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-dystrophic myotonias have been linked to loss-of-function mutations in the ClC-1 chloride channel or gain-of-function mutations in the Na

Indexed as

Chloride ChannelsFemaleGenetic TestingHumansMaleMiddle AgedMutationMyotoniaMyotonia CongenitaNAV1.4 Voltage-Gated Sodium ChannelPedigreeChloride ChannelsCLC-1 channelNAV1.4 Voltage-Gated Sodium ChannelSCN4A protein, humanchloride channelelectrophysiologymyotoniasodium channelstructure analysisXenopus oocytes

Identifiers

PMID33670307
PMCPMC7918176
OpenAlexW3127926930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.