Evidence map›Paper›PMID 33670182›Full record

ArticleViruses2021

VOC 202012/01 Variant Is Effectively Neutralized by Antibodies Produced by Patients Infected before Its Diffusion in Italy.

Valeria Rondinone, Lorenzo Pace, Antonio Fasanella, Viviana Manzulli, Antonio Parisi, Maria Rosaria Capobianchi, Angelo Ostuni, Maria Chironna, Elisabetta Caprioli, Maria Labonia and 6 more

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Valeria RondinoneIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Lorenzo PaceIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Antonio FasanellaIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Viviana ManzulliIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Antonio ParisiIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Maria Rosaria CapobianchiLaboratory of Virology, National Institute for Infectious Diseases "L. Spallanzani", 00149 Roma, Italy.
Angelo OstuniTransfusional Medicine Unit, University-Hospital Policlinico, 70124 Bari, Italy.ORCID 0000-0001-8391-7938
Maria ChironnaDepartment of Biomedical Sciences and Human Oncology-Hygiene Section, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-1043-1256
Elisabetta CaprioliClinical Pathology Laboratory, "Di Miccoli" Hospital, 70051 Barletta, Italy.
Maria LaboniaMicrobiology Laboratory, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Dora CipollettaIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Ines Della RovereIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Luigina SerrecchiaIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Fiorenza PetruzziIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Germana PennuzziIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.
Domenico GalanteIstituto Zooprofilattico Sperimentale of Puglia and Basilicata, 71121 Foggia, Italy.ORCID 0000-0002-1159-2801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (Covid-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and presents a global health emergency that needs urgent intervention. Viruses constantly change through mutation, and new variants of a virus are expected to occur over time. In the United Kingdom (UK), a new variant called B.1.1.7 has emerged with an unusually large number of mutations. The aim of this study is to evaluate the level of protection of sera from 12 patients infected and later healed in Apulia Region (Italy) with Covid-19 between March and November 2020, when the English variant was not circulating in this territory yet, against the new VOC 202012/01 variant by seroneutralization assay. The sera of patients had already been tested before, using a virus belonging to the lineage B.1 and showed an antibody neutralizing titer ranging between 1:160 and 1:320. All the 12 sera donors confirmed the same titers of neutralizing antibodies obtained with a strain belonging to the lineage B.1.1.7 (VOC 202012/01). These data indicate that antibodies produced in subjects infected with variants of Sars-CoV-2 strain before the appearance of the English one, seem to have a neutralizing power also against this variant.

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralChlorocebus aethiopsCOVID-19HumansItalyNeutralization TestsPandemicsSARS-CoV-2United KingdomVero CellsAntibodies, NeutralizingAntibodies, ViralCovid-19neutralizing antibodiesSARS-CoV-2 VOC 202012/01 variant

Identifiers

PMID33670182
PMCPMC7916909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.