Evidence map›Paper›PMID 33669901›Full record

ArticleBiomolecules2021

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.

Marta Tesi, Marco Bugliani, Gianmarco Ferri, Mara Suleiman, Carmela De Luca, Emanuele Bosi, Matilde Masini, Vincenzo De Tata, Conny Gysemans, Francesco Cardarelli and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Effects of Intermittent Fasting-Mimicking Diet on Pancreatic Islet Plasticity: Immunohistochemical, Ultrastructural, and Metabolic Profiles.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Marta TesiPancreatic Islet Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Marco BuglianiPancreatic Islet Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-1744-1561
Gianmarco FerriNEST-Scuola Normale Superiore, Istituto Nanoscienze-CNR (CNR-NANO), 56127 Pisa, Italy.
Mara SuleimanPancreatic Islet Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Carmela De LucaPancreatic Islet Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Emanuele BosiPancreatic Islet Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Matilde MasiniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Vincenzo De TataDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Conny GysemansClinical and Experimental Endocrinology (CEE), Katholieke Universiteit Leuven (KU LEUVEN), 3000 Leuven, Belgium.
Francesco CardarelliNEST-Scuola Normale Superiore, Istituto Nanoscienze-CNR (CNR-NANO), 56127 Pisa, Italy.ORCID 0000-0003-3049-5940
Miriam CnopULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.ORCID 0000-0002-5112-1692
Decio L EizirikULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Piero MarchettiPancreatic Islet Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Lorella MarselliPancreatic Islet Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-6698-2962
University of Pisa · ITIstituto Nanoscienze · ITUniversité Libre de Bruxelles · BEKU Leuven · BE

Funding

Innovative Medicines Initiative 2, Union's Horizon 2020 research and innovation programme, "EFPIA", "JDRF" and "The Leona M. and Harry B. Helmsley Charitable Trust" 115797Innovative Medicines Initiative 2, Union's Horizon 2020 research and innovation programme, "EFPIA", "JDRF" and "The Leona M. and Harry B. Helmsley Charitable Trust" 945268Italian Ministry of University and Research 2017KAM2R5_005Italian Ministry of University and Research 2017YF9FBS
6 · The paper itself

Abstract

The presence of islet cells double positive for insulin and glucagon (Ins

Indexed as

ApoptosisInflammationAdultAgedAged, 80 and overCytokinesDiabetes Mellitus, Type 1FemaleGlucagonHumansInsulinInsulin-Secreting CellsIslets of LangerhansMaleMiddle AgedPancreasCytokinesGlucagonInsulinapoptosiscytokinesdiabetesglucagonhuman isletsinsulinα-cellsβ-cells

Identifiers

PMID33669901
PMCPMC7923272
OpenAlexW3130925519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.