Evidence map›Paper›PMID 33669851›Full record

ReviewMarine drugs2021

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy.

Qi-Ting Zhang, Ze-Dong Liu, Ze Wang, Tao Wang, Nan Wang, Ning Wang, Bin Zhang, Yu-Fen Zhao

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Extraction of pH-Dependent DNA-Binding Anti-Tumoral Peptides fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Biological Activity of Peptide Fraction Derived fromInternational journal of molecular sciences · 2025
    Article
  17. Article
  18. Review
  19. Review
  20. Exploring the seas for cancer cures: the promise of marine-derived bioactive peptide.International journal of biochemistry and molecular biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Qi-Ting ZhangInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.
Ze-Dong LiuLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.
Ze WangLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.
Tao WangInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.
Nan WangQuality Assurance Department, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518057, China.
Ning WangInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.ORCID 0000-0002-5625-5358
Bin ZhangLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.ORCID 0000-0002-4371-4746
Yu-Fen ZhaoInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.
Ningbo University · CN

Funding

foundation of Ningbo University for Grant XYL20023the National 111 Project of China D16013the National Natural Science Foundation of China 91856126the Natural Science Foundation of Ningbo City 2018A610410
6 · The paper itself

Abstract

Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. This paper highlights the anticancer linear and cyclic small peptides in marine resources and presents a review of peptides and the derivatives and their mechanisms.

Indexed as

AnimalsAntineoplastic AgentsAquatic OrganismsHumansNeoplasmsPeptidesPeptides, CyclicAntineoplastic AgentsPeptidesPeptides, Cyclicanticancer medicinecyclic peptideliner peptidemarine organismsmall peptide

Identifiers

PMID33669851
PMCPMC7923226
OpenAlexW3129784577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.