ReviewJournal of clinical medicine2021
Early Diagnostics and Early Intervention in Neurodevelopmental Disorders-Age-Dependent Challenges and Opportunities.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07267442 (Turkish Translation , Validity and Reliability of the Hypertonia Assessment Tool in Children With Motor Disorders), which is not on this map. Cited by 85 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Turkish Translation , Validity and Reliability of the Hypertonia Assessment Tool in Children With Motor Disorders
Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- The intelligent neonatal healthcare: a systematic review of machine learning architectures integrating the internet of medical things and blockchain.Frontiers in artificial intelligence · 2026Pooled it
- Artificial intelligence support for diagnosis of neurodevelopmental disorders during childhood: an umbrella review.Frontiers in psychiatry · 2026Pooled it
- Neurodevelopmental screening for neonates less than 44 weeks gestation in low-income and middle-income countries: a systematic review.BMJ global health · 2025Pooled it
- Serious gaming and eye-tracking for the screening, monitoring, and diagnosis of neurodevelopmental disorders in children: a systematic literature review.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Automated Detection of Neurodevelopmental Disorders Using Face-to-Face Mobile Technology Among Typically Developing Greek Children: Randomized Controlled Trial.JMIR formative research · 2024Trial
- Early, Intensive, Lower Extremity Rehabilitation Shows Preliminary Efficacy After Perinatal Stroke: Results of a Pilot Randomized Controlled Trial.Neurorehabilitation and neural repair · 2022Trial
- Article
- General movements and neurodevelopmental outcomes at 2 years of age in infants born very preterm.Developmental medicine and child neurology · 2026Article
- Longitudinal developmental profiles in 4- to 5-year-old Dutch children: a latent profile analysis.European child & adolescent psychiatry · 2026Article
- Early cerebral palsy risk screening through wearable accelerometry in infants under nine weeks.Scientific reports · 2026Article
- Barriers and facilitators to neurodevelopmental follow-up among at-risk newborns across Washington State.Research square · 2026Article
- Understanding barriers to rehabilitation: child and family determinants of service utilisation in the Enabling Inclusion programme in rural South India.BMJ paediatrics open · 2026Article
- Toward preventive interventions in developmental coordination disorder: in need of early behavioral markers?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Neurodevelopmental outcomes in children with craniosynostosis: a retrospective cross-sectional analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Manual and automated assessments of general movements in neonates are associated with early autism risk at 18 months.Scientific reports · 2026Article
- [Interpretation of the "International consensus on early rehabilitation and nutritional management for infants at high risk of neurological impairment"].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Sensory Reinforcement Feedback Using Movement-Controlled Smartphone App Facilitates Movement in Infants with Neurodevelopmental Disorders: A Pilot Study.Sensors (Basel, Switzerland) · 2026Article
- Applying artificial intelligence in neurodevelopmental disorders management and research.European journal of medical research · 2026Review
- Unsupervised Machine Learning in the Evaluation of Telerehabilitation Interventions for Reading Fluency.International journal of telerehabilitation · 2026Article
- Theoretical framework of the neuro and psychomotor therapist for developmental age: an Italian perspective for paediatric rehabilitation of neurodevelopmental disabilities.Frontiers in medicine · 2026Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review discusses early diagnostics and early intervention in developmental disorders in the light of brain development. The best instruments for early detection of cerebral palsy (CP) with or without intellectual disability are neonatal magnetic resonance imaging, general movements assessment at 2-4 months and from 2-4 months onwards, the Hammersmith Infant Neurological Examination and Standardized Infant NeuroDevelopmental Assessment. Early detection of autism spectrum disorders (ASD) is difficult; its first signs emerge at the end of the first year. Prediction with the Modified Checklist for Autism in Toddlers and Infant Toddler Checklist is possible to some extent and improves during the second year, especially in children at familial risk of ASD. Thus, prediction improves substantially when transient brain structures have been replaced by permanent circuitries. At around 3 months the cortical subplate has dissolved in primary motor and sensory cortices; around 12 months the cortical subplate in prefrontal and parieto-temporal cortices and cerebellar external granular layer have disappeared. This review stresses that families are pivotal in early intervention. It summarizes evidence on the effectiveness of early intervention in medically fragile neonates, infants at low to moderate risk, infants with or at high risk of CP and with or at high risk of ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.