Evidence map›Paper›PMID 33669601›Full record

ArticleInternational journal of molecular sciences2021

Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead.

Xing Lu, Yong Long, Xixi Li, Lang Zhang, Qing Li, Hua Wen, Shan Zhong, Zongbin Cui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. The RNA mPlant biotechnology journal · 2026
    Article
  2. Toxicogenomics and Molecular Markers in Pollution.International journal of molecular sciences · 2022
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xing LuKey Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Yong LongState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.ORCID 0000-0001-6439-0181
Xixi LiDepartment of Genetics, Wuhan University, Wuhan 430071, China.
Lang ZhangDepartment of Genetics, Wuhan University, Wuhan 430071, China.
Qing LiState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Hua WenKey Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Shan ZhongDepartment of Genetics, Wuhan University, Wuhan 430071, China.
Zongbin CuiState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.ORCID 0000-0002-3443-3168
Chinese Academy of Sciences · CNWuhan University · CNMinistry of Agriculture and Rural Affairs · CN

Funding

he State Key Laboratory of Freshwater Ecology and Biotechnology 2016FB09Medical Science Advancement Program (Basic Medical Science) of Wuhan University TFJC2018003National Natural Science Foundation of China 31602129, 31172395 and 31872554the Key-Area Research and Development Program of Guangdong Province 2020B0202080005the Special Fund Project for Guangdong Academy of Sciences to Build Domestic First-class Re-search institutions) 2021GDASYL-20210102003
6 · The paper itself

Abstract

Lead (Pb) is one of the major heavy metals that are toxic to vertebrates and usually considered as environmental pollutants. ABCC4/MRP4 is an organic anion transporter that mediates cellular efflux of a wide range of exogenous and endogenous compounds such as cyclic nucleotides and anti-cancer drugs; however, it remains unclear whether ABCC4 and its orthologs function in the detoxification and excretion of toxic lead. In this study, we found that the transcriptional and translational expression of zebrafish

Indexed as

Gene Knockout TechniquesAnimalsAnimals, Genetically ModifiedATP-Binding Cassette, Sub-Family C ProteinsBase SequenceBiological TransportGene Expression Regulation, DevelopmentalInactivation, MetabolicLeadLLC-PK1 CellsMutationSwineZebrafishZebrafish ProteinsAbcc4 protein, zebrafishATP-Binding Cassette, Sub-Family C ProteinsLeadZebrafish ProteinsAbcc4detoxificationefflux transporterknockoutleadtransgenesiszebrafish

Identifiers

PMID33669601
PMCPMC7923114
OpenAlexW3129402424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.