Evidence map›Paper›PMID 33669597›Full record

ReviewVaccines2021

Multiple Levels of Immunological Memory and Their Association with Vaccination.

Zsófia Bugya, József Prechl, Tibor Szénási, Éva Nemes, Attila Bácsi, Gábor Koncz

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. mBio · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Frontiers in immunology · 2023
    Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zsófia BugyaDepartment of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
József PrechlR&D Laboratory, Diagnosticum Zrt, H-1047 Budapest, Hungary.ORCID 0000-0003-3859-4353
Tibor SzénásiDepartment of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Éva NemesClinical Center, Department of Pediatrics, University of Debrecen, H-4032 Debrecen, Hungary.
Attila BácsiDepartment of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Gábor KonczDepartment of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
University of Debrecen · HU

Funding

European Union and the European Regional Development Fund GINOP-2.3.2-15-2016-00050National Research, Development and Innovation Office K 125224Versenyképes Közép-Magyarország Operatív Program VEKOP-2.1.1-15-2016-00098
6 · The paper itself

Abstract

Immunological memory is divided into many levels to counteract the provocations of diverse and ever-changing infections. Fast functions of effector memory and the superposition of both quantitatively and qualitatively plastic anticipatory memory responses together form the walls of protection against pathogens. Here we provide an overview of the role of different B and T cell subsets and their interplay, the parallel and independent functions of the B1, marginal zone B cells, T-independent- and T-dependent B cell responses, as well as functions of central and effector memory T cells, tissue-resident and follicular helper T cells in the memory responses. Age-related limitations in the immunological memory of these cell types in neonates and the elderly are also discussed. We review how certain aspects of immunological memory and the interactions of components can affect the efficacy of vaccines, in order to link our knowledge of immunological memory with the practical application of vaccination.

Indexed as

B cellelderlyimmunological memorynewbornT cellvaccination

Identifiers

PMID33669597
PMCPMC7922266
OpenAlexW3132713125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.