Evidence map›Paper›PMID 33669452›Full record

ArticleInternational journal of molecular sciences2021

Sex Differences in Photoprotective Responses to 1,25-Dihydroxyvitamin D3 in Mice Are Modulated by the Estrogen Receptor-β.

Wannit Tongkao-On, Chen Yang, Bianca Y McCarthy, Warusavithana G Manori De Silva, Mark S Rybchyn, Clare Gordon-Thomson, Katie M Dixon, Gary M Halliday, Vivienne E Reeve, Rebecca S Mason

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wannit Tongkao-OnDepartment of Physiology, University of Sydney, Sydney, NSW 2006, Australia.
Chen YangDepartment of Physiology, University of Sydney, Sydney, NSW 2006, Australia.
Bianca Y McCarthyDepartment of Physiology, University of Sydney, Sydney, NSW 2006, Australia.
Warusavithana G Manori De SilvaDepartment of Physiology, University of Sydney, Sydney, NSW 2006, Australia.
Mark S RybchynDepartment of Physiology, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-4336-6227
Clare Gordon-ThomsonDepartment of Physiology, University of Sydney, Sydney, NSW 2006, Australia.
Katie M DixonAnatomy and Histology, University of Sydney, Sydney, NSW 2006, Australia.
Gary M HallidayDermatology, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Vivienne E ReeveFaculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia.
Rebecca S MasonDepartment of Physiology, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-1534-9697
The University of Sydney · AU

Funding

Australian Research Council LP100200680National Health and Medical Research Council 512476
6 · The paper itself

Abstract

Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than in female humans and mice and is exacerbated in female estrogen receptor-beta knockout (ER-β-/-) mice. We previously reported that the active vitamin D hormone, 1,25-dihydroxyvitamin D3 (1,25(OH)2D), applied topically protects against the ultraviolet radiation (UV) induction of cutaneous cyclobutane pyrimidine dimers (CPDs) and the suppression of contact hypersensitivity (CHS) in female mice. Here, we compare these responses in female versus male Skh:hr1 mice, in ER-β-/-/-- versus wild-type C57BL/6 mice, and in female ER-blockaded Skh:hr1 mice. The induction of CPDs was significantly greater in male than female Skh:hr1 mice and was more effectively reduced by 1,25(OH)2D in female Skh:hr1 and C57BL/6 mice than in male Skh:hr1 or ER-β-/- mice, respectively. This correlated with the reduced sunburn inflammation due to 1,25(OH)2D in female but not male Skh:hr1 mice. Furthermore, although 1,25(OH)2D alone dose-dependently suppressed basal CHS responses in male Skh:hr1 and ER-β-/- mice, UV-induced immunosuppression was universally observed. In female Skh:hr1 and C57BL/6 mice, the immunosuppression was decreased by 1,25(OH)2D dose-dependently, but not in male Skh:hr1, ER-β-/-, or ER-blockaded mice. These results reveal a sex bias in genetic, inflammatory, and immune photoprotection by 1,25(OH)2D favoring female mice that is dependent on the presence of ER-β.

Indexed as

Ultraviolet RaysAdministration, CutaneousAnimalsCalcitriolDermatitis, ContactDisease Models, AnimalEstrogen Receptor betaFemaleImmune ToleranceImmunohistochemistryMaleMiceMice, Inbred C57BLMice, KnockoutPyrimidine DimersSex FactorsCalcitriolEstrogen Receptor betaPyrimidine DimersSunscreening Agents1α,25-dihydroxyvitaminD3cyclobutane pyrimidine dimersDNA damageedemaER-β knockoutfemale vs. male micephotoimmune suppressionphotoprotection

Identifiers

PMID33669452
PMCPMC7920427
OpenAlexW3129945122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.