ArticleHealthcare (Basel, Switzerland)2021
Chronotropic Incompetence Limits Aerobic Exercise Capacity in Patients Taking Beta-Blockers: Real-Life Observation of Consecutive Patients.
Article in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Age-Stratified Prognostic Comparison of Three Chronotropic Incompetence Definitions in Patients with Suspected Coronary Artery Disease Undergoing Exercise Stress SPECT-MPI.Clinical interventions in aging · 2026Article
- The Role of Mechanical Economy and Efficiency as Key Drivers of Cardiac Rehabilitation Exercise Performance Improvement in a Patient With Heart Failure and an Implanted CRT-D: A Case Report and Literature Review.Clinical case reports · 2025Article
- The Role of Renal Denervation in HFpEF.Journal of clinical medicine · 2025Review
- The effect of chronotropic incompetence on physiologic responses during progressive exercise in people with Parkinson's disease.European journal of applied physiology · 2024Article
- Heart Rate Recovery: Up to Date in Heart Failure-A Literature Review.Journal of clinical medicine · 2024Review
- Rate-Responsive Cardiac Pacing: Technological Solutions and Their Applications.Sensors (Basel, Switzerland) · 2023Review
- Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundChronotropic incompetence in patients taking beta-blockers is associated with poor prognosis; however, its impact on exercise capacity (EC) remains unclear.
methodsWe analyzed data from consecutive patients taking beta-blockers referred for cardiopulmonary exercise testing to assess EC. Chronotropic incompetence was defined as chronotropic index (CI) ≤ 62%.
resultsAmong 140 patients all taking beta-blockers (age 61 ± 9.7 years; 73% males), 64% with heart failure, chronotropic incompetence was present in 80.7%. EC assessed as peak oxygen uptake was lower in the group with chronotropic incompetence, 18.3 ± 5.7 vs. 24.0 ± 5.3 mL/kg/min,
conclusionsIn patients taking beta-blockers, presence of chronotropic incompetence was associated with lower EC, regardless of the beta-blocker dose. CI accounted for more than one-third of EC variance explained by our model.
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