Evidence map›Paper›PMID 33669364›Full record

ReviewJournal of personalized medicine2021

Precision Medicine and Public Health: New Challenges for Effective and Sustainable Health.

Deborah Traversi, Alessandra Pulliero, Alberto Izzotti, Elena Franchitti, Licia Iacoviello, Francesco Gianfagna, Alessandro Gialluisi, Benedetta Izzi, Antonella Agodi, Martina Barchitta and 15 more

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  13. Health disparities in the risk of severe acidosis: real-world evidence from the All of Us cohort.Journal of the American Medical Informatics Association : JAMIA · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Deborah TraversiDepartment of Public Health and Pediatrics, University of Torino, Piazza Polonia 94, 10126 Torino, Italy.ORCID 0000-0002-7328-1339
Alessandra PullieroDepartment of Health Sciences School of Medicine, University of Genoa, 16132 Genova, Italy.ORCID 0000-0001-5378-9517
Alberto IzzottiDepartment of Experimental Medicine, University of Genoa, 16132 Genova, Italy.
Elena FranchittiDepartment of Public Health and Pediatrics, University of Torino, Piazza Polonia 94, 10126 Torino, Italy.
Licia IacovielloResearch Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
Francesco GianfagnaResearch Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-4615-0816
Alessandro GialluisiDepartment of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, Italy.
Benedetta IzziDepartment of Epidemiology and Prevention, IRCCS NEUROMED, 86077 Pozzilli, Italy.
Antonella AgodiDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0002-4405-8162
Martina BarchittaDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0002-0905-5003
Giovanna Elisa CalabròSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.ORCID 0000-0003-0259-3797
Ilda HoxhajSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.ORCID 0000-0001-7086-2456
Michele SassanoSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
Luca Gino SbrogiòDipartimento di Prevenzione, Az. ULSS3 Serenissima, 30174 Venezia, Italy.ORCID 0000-0003-1391-8841
Annamaria Del SoleDipartimento di Prevenzione, SIAN, Az. ULSS5, 45100 Rovigo, Italy.
Francesco MarchioriAzienda Ospedaliera Universitaria Integrata di Verona, 37126 Verona, Italy.ORCID 0000-0002-2187-1329
Erica PitiniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy.
Giuseppe MigliaraDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy.
Carolina MarzuilloDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy.
Corrado De VitoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy.
Manuela TamburroDepartment of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy.ORCID 0000-0003-2454-4435
Michela Lucia SammarcoDepartment of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy.
Giancarlo RipabelliDepartment of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy.
Paolo VillariDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy.
Stefania BocciaSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of high-throughput omics technologies represents an unmissable opportunity for evidence-based prevention of adverse effects on human health. However, the applicability and access to multi-omics tests are limited. In Italy, this is due to the rapid increase of knowledge and the high levels of skill and economic investment initially necessary. The fields of human genetics and public health have highlighted the relevance of an implementation strategy at a national level in Italy, including integration in sanitary regulations and governance instruments. In this review, the emerging field of public health genomics is discussed, including the polygenic scores approach, epigenetic modulation, nutrigenomics, and microbiomes implications. Moreover, the Italian state of implementation is presented. The omics sciences have important implications for the prevention of both communicable and noncommunicable diseases, especially because they can be used to assess the health status during the whole course of life. An effective population health gain is possible if omics tools are implemented for each person after a preliminary assessment of effectiveness in the medium to long term.

Indexed as

early disease preventionepigenetic modulationsgenetic and microbiome markersgenetic polymorphismshealth technology assessmentmiRNApublic health genomics

Identifiers

PMID33669364
PMCPMC7920275

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.