Evidence map›Paper›PMID 33669361›Full record

ReviewInternational journal of molecular sciences2021

Context-Dependent Roles of RNA Modifications in Stress Responses and Diseases.

Emma Wilkinson, Yan-Hong Cui, Yu-Ying He

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 61 citations in OpenAlex.

  1. Mechanistic Insights Into the Oxidative Reactivity of 2-Selenouridine in tRNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Emerging roles of RNA mInternational journal of oncology · 2026
    Review
  6. Bioluminescent Probes for Multiplexed RNA Imaging.Journal of the American Chemical Society · 2026
    Article
  7. Review
  8. Article
  9. NSUN7 is a catalytically inactive RNA mNature communications · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. NAging and disease · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. ExploringHorticulture research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emma WilkinsonDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-3468-0326
Yan-Hong CuiDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637, USA.
Yu-Ying HeDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-2665-7962
University of Chicago · US

Funding

Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
YTHDF2 and UVB damage response in skin cancerR01ES024373 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2015 to 2023
$4.3M
The mechanistic role of METTL14 in UVB-induced skin tumorigenesisR01ES030576 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2019 to 2023
$3.0M
FTO and RNA methylation in arsenic tumorigenicityR01ES031534 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2020 to 2022
$1.2M
NCI NIH HHS T32 CA009594NIEHS NIH HHS R01 ES024373NIEHS NIH HHS R01 ES030576NIEHS NIH HHS R01 ES031534NIH HHS ES031534, ES024373, ES030576
6 · The paper itself

Abstract

RNA modifications are diverse post-transcriptional modifications that regulate RNA metabolism and gene expression. RNA modifications, and the writers, erasers, and readers that catalyze these modifications, serve as important signaling machineries in cellular stress responses and disease pathogenesis. In response to stress, RNA modifications are mobilized to activate or inhibit the signaling pathways that combat stresses, including oxidative stress, hypoxia, therapeutic stress, metabolic stress, heat shock, DNA damage, and ER stress. The role of RNA modifications in response to these cellular stressors is context- and cell-type-dependent. Due to their pervasive roles in cell biology, RNA modifications have been implicated in the pathogenesis of different diseases, including cancer, neurologic and developmental disorders and diseases, and metabolic diseases. In this review, we aim to summarize the roles of RNA modifications in molecular and cellular stress responses and diseases.

Indexed as

DNA DamageEndoplasmic Reticulum StressHeat-Shock ResponseOxidative StressRNA Processing, Post-TranscriptionalStress, PhysiologicalAnimalsHumansHypoxiaMetabolic DiseasesNeoplasmsNervous System DiseasesRNARNAcellular stressdiseasem6ARNA modifications

Identifiers

PMID33669361
PMCPMC7920320
OpenAlexW3129925157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.