Evidence map›Paper›PMID 33669350›Full record

ArticleCancers2021

Intracellular Autofluorescence as a New Biomarker for Cancer Stem Cells in Glioblastoma.

Joana Vieira de Castro, Céline S Gonçalves, Eduarda P Martins, Irene Miranda-Lorenzo, Mariana T Cerqueira, Adhemar Longatto-Filho, Afonso A Pinto, Rui L Reis, Nuno Sousa, Christopher Heeschen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Choosing the Probe for Single-Molecule Fluorescence Microscopy.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Joana Vieira de CastroLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus Gualtar, University of Minho, 4710-057 Braga, Portugal.
Céline S GonçalvesLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus Gualtar, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-3713-119X
Eduarda P MartinsLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus Gualtar, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-4248-7457
Irene Miranda-LorenzoStem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Mariana T CerqueiraICVS/3B's-PT Government Associate Laboratory, 4710-057/4805-017 Braga/Guimarães, Portugal.ORCID 0000-0002-2430-7758
Adhemar Longatto-FilhoLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus Gualtar, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-5779-9752
Afonso A PintoDepartment of Neurosurgery, Hospital de Braga, 4710-243 Braga, Portugal.
Rui L ReisICVS/3B's-PT Government Associate Laboratory, 4710-057/4805-017 Braga/Guimarães, Portugal.
Nuno SousaLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus Gualtar, University of Minho, 4710-057 Braga, Portugal.
Christopher HeeschenStem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Bruno M CostaLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus Gualtar, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0003-4861-7432
University of Minho · PTHospital Braga · PTShanghai Jiao Tong University · CNSpanish National Cancer Research Centre · ESUniversidade de São Paulo · BR

Funding

European Regional Development Fund NORTE-01-0145-FEDER-000013European Regional Development Fund NORTE-01-0145-FEDER-000023European Regional Development Fund NORTE-01-0246-FEDER-000012European Regional Development Fund POCI-01-0145-FEDER-007038Fundação Calouste Gulbenkian -Fundação para a Ciência e a Tecnologia IF/00601/2012Fundação para a Ciência e a Tecnologia PD/BDE/143154/2019Fundação para a Ciência e a Tecnologia PTDC/SAU-GMG/113795/2009Fundação para a Ciência e a Tecnologia SFRH/BD/88121/2012Fundação para a Ciência e a Tecnologia SFRH/BD/92786/2013Liga Portuguesa Contra o Cancro -
6 · The paper itself

Abstract

The identification of cancer stem cells (CSCs), which are implicated in tumor initiation, progression, therapy resistance, and relapse, is of great biological and clinical relevance. In glioblastoma (GBM), this is still a challenge, as no single marker is able to universally identify populations of GBM cancer stem cells (GSCs). Indeed, there is still controversy on whether biomarker-expressing cells fulfill the functional criteria of bona fide GSCs, despite being widely used. Here, we describe a novel subpopulation of autofluorescent (Fluo

Indexed as

autofluorescencebiomarkercancer stem cellsglioblastoma stem cellsvitamin B2

Identifiers

PMID33669350
PMCPMC7920313
OpenAlexW3132252990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.