Evidence map›Paper›PMID 33669265›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease.

Noriyoshi Ogino, Fusao Ikeda, Shihoko Namba, Shinnosuke Ohkubo, Tomoaki Nishimura, Hiroyuki Okada, Satoshi Hirohata, Narufumi Suganuma, Keiki Ogino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Noriyoshi OginoDepartment of Environmental Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku City 783-8505, Japan.ORCID 0000-0002-1877-7577
Fusao IkedaDepartment of Gastroenterology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Shihoko NambaCenter for Innovative Clinical Medicine, Okayama University Hospital, Okayama, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Shinnosuke OhkuboDepartment of Medical Technology, Graduate School of Health Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Tomoaki NishimuraMicro Blood Science Inc., 2-14-8 Iwamotocho, Chiyoda-ku, Tokyo 101-0032, Japan.
Hiroyuki OkadaDepartment of Gastroenterology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Satoshi HirohataDepartment of Medical Technology, Graduate School of Health Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan.ORCID 0000-0002-4815-5891
Narufumi SuganumaDepartment of Environmental Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku City 783-8505, Japan.
Keiki OginoDepartment of Environmental Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku City 783-8505, Japan.
Okayama University · JPKōchi University · JPOkayama University Hospital · JPUniversity of Occupational and Environmental Health Japan · JP

Funding

Micro Blood Science Inc. none
6 · The paper itself

Abstract

While plasma arginase-1 has been suggested as a biomarker of mental status in healthy individuals, it has not been evaluated in patients with chronic liver disease. This cross-sectional study investigated the utility of plasma arginase-1 for screening mental status in patients with chronic liver disease. This study included outpatients with chronic liver disease who underwent regular check-ups at Okayama University Hospital between September 2018 and January 2019. In addition to the standard blood tests, the plasma arginase-1 level was analyzed. The patients' mental status was assessed using the Japanese version of the General Health Questionnaire-28 (GHQ-28). The associations between mental status and various parameters, including plasma arginase-1, were investigated using logistic regression analysis. Among 114 participating patients, 8 were excluded, comprising 6 with insufficient blood samples for plasma arginase-1 measurement and 2 with incomplete questionnaires. Multivariate binomial logistic regression analysis revealed that plasma arginase-1 was significantly and negatively associated with the GHQ-total score, especially somatic symptoms. Therefore, plasma arginase-1 may be a useful biomarker for assessing the mental status of outpatients with chronic liver disease.

Indexed as

arginaseliver diseasemental status

Identifiers

PMID33669265
PMCPMC7920070
OpenAlexW3131667601

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.