Evidence map›Paper›PMID 33669210›Full record

ReviewChildren (Basel, Switzerland)2021

Using Mediation Analysis to Understand How Treatments for Paediatric Pain Work: A Systematic Review and Recommendations for Future Research.

Hayley B Leake, G Lorimer Moseley, Tasha R Stanton, Lauren C Heathcote, Joshua W Pate, Michael A Wewege, Hopin Lee

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hayley B LeakeIIMPACT in Health, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0002-6133-2186
G Lorimer MoseleyIIMPACT in Health, University of South Australia, Adelaide, SA 5000, Australia.
Tasha R StantonIIMPACT in Health, University of South Australia, Adelaide, SA 5000, Australia.
Lauren C HeathcoteDepartment of Anaesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Joshua W PateDepartment of Physiotherapy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2008, Australia.ORCID 0000-0002-1049-3916
Michael A WewegeCentre for Pain IMPACT, Neuroscience Research Australia, Sydney, NSW 2031, Australia.ORCID 0000-0002-3283-2149
Hopin LeeCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK.ORCID 0000-0001-5692-0314

Funding

Department of Education, Skills and Employment, Australian Government Research Training Program scholarshipNational Health and Medical Research Council APP1126767National Health and Medical Research Council ID1141735National Health and Medical Research Council ID1178444National Health and Medical Research Council Postgraduate ScholarshipStanford Maternal and Child Health Research Institute postdoctoral support award
6 · The paper itself

Abstract

Clinicians have an increasing number of evidence-based interventions to treat pain in youth. Mediation analysis offers a way of investigating how interventions work, by examining the extent to which an intermediate variable, or mediator, explains the effect of an intervention. This systematic review examined studies that used mediation analysis to investigate mechanisms of interventions on pain-relevant outcomes for youth (3-18 years) with acute or chronic pain, and provides recommendations for future mediation research in this field. We searched five electronic databases for clinical trials or observational longitudinal studies that included a comparison group and conducted mediation analyses of interventions on youth and assessed pain outcomes. We found six studies (

Indexed as

acute painchronic painmediation analysispaediatricpain

Identifiers

PMID33669210
PMCPMC7919827

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.