ReviewJournal of clinical medicine2021
The Oral Microbiota Changes in Orthodontic Patients and Effects on Oral Health: An Overview.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06641960 (The Effectiveness of Probiotics on Oral Health During Adult Orthodontic Treatment With Fixed Appliances), which is not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effectiveness of Probiotics on Oral Health During Adult Orthodontic Treatment With Fixed Appliances: A Two-arm Parallel-group Randomized Controlled Clinical Trial
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- The efficacy of mouthwashes on oral microorganisms and gingivitis in patients undergoing orthodontic treatment: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Impact of Z-spring appliance and clear aligner therapy on oral microorganisms in children: A clinical trial.Saudi medical journal · 2025Trial
- Cleansing efficacy of an oral irrigator with microburst technology in adolescent orthodontic patients. A randomized-controlled crossover study.Clinical oral investigations · 2024Trial
- The effectiveness of water jet flossing and interdental flossing for oral hygiene in orthodontic patients with fixed appliances: a randomized clinical trial.BMC oral health · 2024Trial
- Cleansing efficacy of an oral irrigator with microburst technology in orthodontic patients-a randomized-controlled crossover study.Clinical oral investigations · 2023Trial
- Histogram-Corrected Intraoral Photographs for Early Gingivitis Screening in Orthodontic Patients.International journal of dental hygiene · 2026Article
- Efficacy of Dual-Light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment: A Randomized, Assessor-Blinded and Controlled Trial.Dentistry journal · 2026Article
- Hydroxyapatite-Based 3D Tooth Models for Investigating Spatially Resolved Analysis of Biofilm Formation Dynamics.ACS applied bio materials · 2026Article
- Effects of demineralization around orthodontic brackets bonded with different adhesive agents on fatigue-based shear bond strength: an in vitro comparative study.BMC oral health · 2026Article
- Observational Study of the Association Between OralJournal of clinical medicine · 2026Article
- Impact of rapid maxillary expansion on nasal microbiota in mouth-breathing children: a prospective cohort study.BMC oral health · 2026Article
- Effect of cigarette smoke on surface roughness and bacterial adhesion of orthodontic aligners: an in vitro investigation.Clinical oral investigations · 2026Article
- Clear aligner therapy beyond esthetics: oral health, polymer materials, and the environmental cost of digital orthodontics.Frontiers in dental medicine · 2026Review
- Effect of Titanium Dioxide Nanotubes on the Shear Bond Strength and Failure Pattern of Metal Orthodontic Brackets Bond to Enamel: An In Vitro Study With Human Teeth.International journal of dentistry · 2026Article
- The comprehensive oral microbiome landscape unveils its interplay with poor oral health in esophageal squamous cell carcinoma risk.Cell reports. Medicine · 2025Article
- Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions.Antonie van Leeuwenhoek · 2025Review
- Optimizing orthodontic treatment for delayed eruption of permanent anterior teeth: A prospective study using a modified appliance.The Saudi dental journal · 2025Article
- Association of Systemic Pathologies on Dental, Periodontal and Orthodontic Status in Children.Biomedicines · 2025Article
- Periodontal Microbial Profiles Across Periodontal Conditions in Pediatric Subjects: A Narrative Review.Microorganisms · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nowadays, there is a considerable interest to study the biological and microbiological changes that accompany orthodontic treatment. Growing knowledge on oral microbiota allows, day after day, to identify and characterize the microbial arrangements specifically associated with oral and extra-oral conditions. The aim of the present work is to highlight any further correlations between orthodontic appliances and the qualitative and quantitative modifications of the oral microbiota, such as predisposing factors for the onset of caries, periodontal diseases, and other infections, which can impact the oral and systemic health of the orthodontic patients. When compared with subjects without orthodontic appliances, orthodontic patients reported significant qualitative and quantitative differences in supra- and subgingival plaque during the entire treatment period. Certain components of fixed appliances (mainly bonded molar brackets, ceramic brackets, and elastomeric ligatures) showed high risks of periodontal disease and tooth decay for patients. An unclear prevalence of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.