ReviewInternational journal of molecular sciences2021
MicroRNA-mRNA Networks in Pregnancy Complications: A Comprehensive Downstream Analysis of Potential Biomarkers.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- MicroRNA Associations with Preterm Labor-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Optimizing protocols for microRNA profiling of infant and toddler stool.RNA biology · 2026Article
- Expression patterns of circulating microRNA in confirmed early-onset and late-onset pre-eclampsia cases.Archives of gynecology and obstetrics · 2026Article
- Folate Deficiency Alters microRNA Expression and Transcriptomic Networks in a Human Trophoblast Model.Nutrients · 2026Article
- PCYT1B-Targeting miRNAs as Potential Biomarkers for Placental Diseases.International journal of molecular sciences · 2026Article
- Alterations in MicroRNA and Cytokine Expressions in Placental and Amniotic Tissues of COVID-19 Affected Pregnant Women.The Kaohsiung journal of medical sciences · 2026Article
- Transcriptome Analysis, Machine Learning, and Experimental Identification of CDK7 Affecting the Progression of Pregnancy-induced Hypertension by Influencing Macrophage Polarization.Current molecular medicine · 2026Article
- First trimester maternal serum MicroRNA expression and pre-eclampsia: a retrospective nested case-control study.BMC pregnancy and childbirth · 2025Article
- Association of Circulating miRNAs from the C19MC Cluster and IGF System with Macrosomia in Women with Gestational Diabetes Mellitus.International journal of molecular sciences · 2025Article
- Intrauterine Growth-Restricted Pig-Associated Testicular Transcriptome Analysis Reveals microRNA-mRNA Regulatory Networks.Animals : an open access journal from MDPI · 2025Article
- Neonates at Risk: Understanding the Impact of High-Risk Pregnancies on Neonatal Health.Medicina (Kaunas, Lithuania) · 2025Review
- Profiling the cell-specific small non-coding RNA transcriptome of the human placenta.Scientific reports · 2025Article
- Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy.Frontiers in endocrinology · 2025Article
- Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies.Frontiers in molecular biosciences · 2025Article
- Small RNAs in the pathogenesis of preeclampsia.Placenta · 2024Review
- Circulating extracellular vesicular microRNA signatures in early gestation show an association with subsequent clinical features of pre-eclampsia.Scientific reports · 2024Article
- RNA-seq reveals differentially expressed lncRNAs and circRNAs and their associated functional network in HTR-8/Svneo cells under hypoxic conditions.BMC medical genomics · 2024Article
- The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy.International journal of molecular sciences · 2024Review
- FGR-associated placental insufficiency and capillary angiogenesis involves disruptions in human placental miRNAs and mRNAs.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnancy complications are a major cause of fetal and maternal morbidity and mortality in humans. The majority of pregnancy complications initiate due to abnormal placental development and function. During the last decade, the role of microRNAs (miRNAs) in regulating placental and fetal development has become evident. Dysregulation of miRNAs in the placenta not only affects placental development and function, but these miRNAs can also be exported to both maternal and fetal compartments and affect maternal physiology and fetal growth and development. Due to their differential expression in the placenta and maternal circulation during pregnancy complications, miRNAs can be used as diagnostic biomarkers. However, the differential expression of a miRNA in the placenta may not always be reflected in maternal circulation, which makes it difficult to find a reliable biomarker for placental dysfunction. In this review, we provide an overview of differentially expressed miRNAs in the placenta and/or maternal circulation during preeclampsia (PE) and intrauterine growth restriction (IUGR), which can potentially serve as biomarkers for prediction or diagnosis of pregnancy complications. Using different bioinformatics tools, we also identified potential target genes of miRNAs associated with PE and IUGR, and the role of miRNA-mRNA networks in the regulation of important signaling pathways and biological processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.