Evidence map›Paper›PMID 33669132›Full record

ArticleViruses2021

Delphine Lapaillerie, Cathy Charlier, Henrique S Fernandes, Sergio F Sousa, Paul Lesbats, Pierre Weigel, Alexandre Favereaux, Véronique Guyonnet-Duperat, Vincent Parissi

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Discovery of Novel Spike Inhibitors against SARS-CoV-2 Infection.International journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Delphine LapaillerieFundamental Microbiology and Pathogenicity Lab (MFP), UMR 5234 CNRS-University of Bordeaux, SFR TransBioMed., 33076 Bordeaux, France.ORCID 0000-0001-9117-0547
Cathy CharlierIMPACT Platform "Interactions Moléculaires Puces ACTivités", UMR CNRS 6286 UFIP, Université de Nantes, F-44000 Nantes, France.
Henrique S FernandesUCIBIO@REQUIMTE, BioSIM-Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0002-9280-1838
Sergio F SousaUCIBIO@REQUIMTE, BioSIM-Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0002-6560-5284
Paul LesbatsFundamental Microbiology and Pathogenicity Lab (MFP), UMR 5234 CNRS-University of Bordeaux, SFR TransBioMed., 33076 Bordeaux, France.ORCID 0000-0002-4623-0675
Pierre WeigelIMPACT Platform "Interactions Moléculaires Puces ACTivités", UMR CNRS 6286 UFIP, Université de Nantes, F-44000 Nantes, France.
Alexandre FavereauxInterdisciplinary Institute for Neuroscience (IINS-CNRS UMR 5297), Centre Broca Nouvelle Aquitaine, 33076 Bordeaux, France.ORCID 0000-0003-0881-9224
Véronique Guyonnet-DuperatVect'UB, Vectorology Platform, INSERM US05 - CNRS UMS 3427- TBM-Core, Université de Bordeaux, 33000 Bordeaux, France.
Vincent ParissiFundamental Microbiology and Pathogenicity Lab (MFP), UMR 5234 CNRS-University of Bordeaux, SFR TransBioMed., 33076 Bordeaux, France.
Centre National de la Recherche Scientifique · FRUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent responsible for the recent coronavirus disease 2019 (COVID-19) pandemic. Productive SARS-CoV-2 infection relies on viral entry into cells expressing angiotensin-converting enzyme 2 (ACE2). Indeed, viral entry into cells is mostly mediated by the early interaction between the viral spike protein S and its ACE2 receptor. The S/ACE2 complex is, thus, the first contact point between the incoming virus and its cellular target; consequently, it has been considered an attractive therapeutic target. To further characterize this interaction and the cellular processes engaged in the entry step of the virus, we set up various

Indexed as

Virus InternalizationAngiotensin-Converting Enzyme 2Computer SimulationCOVID-19HEK293 CellsHumansIn Vitro TechniquesKineticsModels, MolecularMolecular Dynamics SimulationProtein BindingProtein DomainsSARS-CoV-2Spike Glycoprotein, CoronavirusACE2 protein, humanAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVIDSARS-CoV-2Spike/ACE2 complex

Identifiers

PMID33669132
PMCPMC7996581
OpenAlexW3130851094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.