Evidence map›Paper›PMID 33669069›Full record

ArticleInternational journal of molecular sciences2021

Kalkitoxin Reduces Osteoclast Formation and Resorption and Protects against Inflammatory Bone Loss.

Liang Li, Ming Yang, Saroj Kumar Shrestha, Hyoungsu Kim, William H Gerwick, Yunjo Soh

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Synergistic Effect ofBiomolecules · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Metabolic bone disorders and the promise of marine osteoactive compounds.Cellular and molecular life sciences : CMLS · 2023
    Review
  6. Article
  7. Kalkitoxin: A Potent Suppressor of Distant Breast Cancer Metastasis.International journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Liang LiDepartment of Dental Pharmacology, School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.ORCID 0000-0002-0781-9735
Ming YangDepartment of Periodontology, School of Dentistry, Jeonbuk National University, Jeon-Ju 561-756, Korea.
Saroj Kumar ShresthaDepartment of Dental Pharmacology, School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.
Hyoungsu KimCollege of Pharmacy, Ajou University, San 5, Woncheon-dong, Youngtong-gu Suwon 443-749, Korea.ORCID 0000-0002-2774-8727
William H GerwickCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92037, USA.ORCID 0000-0003-1403-4458
Yunjo SohDepartment of Dental Pharmacology, School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.
Jeonbuk National University · KRAjou University · KRScripps Institution of Oceanography · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoclasts, bone-specified multinucleated cells produced by monocyte/macrophage, are involved in numerous bone destructive diseases such as arthritis, osteoporosis, and inflammation-induced bone loss. The osteoclast differentiation mechanism suggests a possible strategy to treat bone diseases. In this regard, we recently examined the in vivo impact of kalkitoxin (KT), a marine product obtained from the marine cyanobacterium

Indexed as

ActinsAnimalsBone DensityBone ResorptionCathepsin KCell SurvivalInflammationJanus KinasesLipidsLipopolysaccharidesLyngbyaMacrophage Colony-Stimulating FactorMacrophagesMaleMAP Kinase Signaling SystemMatrix Metalloproteinase 9Acp5 protein, mouseActinsCathepsin KCSF1 protein, mouseDC-STAMP protein, mouseJanus KinaseskalkitoxinLipidsLipopolysaccharidesMacrophage Colony-Stimulating FactorMatrix Metalloproteinase 9Membrane ProteinsMmp9 protein, mouseNerve Tissue ProteinsNfatc1 protein, mouseNFATC Transcription FactorsProto-Oncogene Proteins c-fosRANK LigandTartrate-Resistant Acid PhosphataseThiazolesTnfsf11 protein, mousebone lossinflammationkalkitoxinmarine natural productosteoclast

Identifiers

PMID33669069
PMCPMC7956546
OpenAlexW3130563364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.