ArticleThe Journal of clinical investigation1988
Role of group-specific component (vitamin D binding protein) in clearance of actin from the circulation in the rabbit.
Article in The Journal of clinical investigation, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- β-Actin: An Emerging Biomarker in Ischemic Stroke.Cellular and molecular neurobiology · 2023Review
- Skeletal Muscle and the Maintenance of Vitamin D Status.Nutrients · 2020Review
- The Role of Skeletal Muscle in Maintaining Vitamin D Status in Winter.Current developments in nutrition · 2019Review
- Vitamin D Binding Protein: A Historic Overview.Frontiers in endocrinology · 2019Review
- Association and expression quantitative trait loci (eQTL) analysis of porcine AMBP, GC and PPP1R3B genes with meat quality traits.Molecular biology reports · 2012Article
- Identification of two distinct cell binding sequences in the vitamin D binding protein.Biochimica et biophysica acta · 2010Article
- Fatty acid-binding site environments of serum vitamin D-binding protein and albumin are different.Bioorganic chemistry · 2008Article
- Cross-talk among structural domains of human DBP upon binding 25-hydroxyvitamin D.Biochemical and biophysical research communications · 2008Article
- 1,25-Dihydroxycholecalciferol inhibits the cochemotactic activity of Gc (vitamin D binding protein).Journal of endocrinological investigation · 1991Article
- Uptake and degradation of filamentous actin and vitamin D-binding protein in the rat.The Biochemical journal · 1991Article
- Uptake and degradation of vitamin D binding protein and vitamin D binding protein-actin complex in vivo in the rat.The Biochemical journal · 1990Article
- Angiopathic consequences of saturating the plasma scavenger system for actin.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- A monoclonal antibody against human vitamin-D-binding protein for the analysis of genetic variation in the group-specific component system (Gc).Human genetics · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 3 countries.
Funding
Abstract
The possible role of group specific component (Gc) (vitamin D-binding protein) in the clearance of cellular actin entering the circulation was examined with 125I-labeled Gc and actin injected into a rabbit model. Although filamentous F-actin is depolymerized primarily by plasma gelsolin, greater than or equal to 90% 125I-actin injected in either monomeric G- or F-form became complexed eventually with Gc (1:1 molar ratio). Clearance of Gc complexes was much faster (greater than 90% within 5 h) than that of native Gc (t1/2 = 17.2 h). Nephrectomy did not significantly alter the clearance of either Gc or actin. Since Gc complexes are dramatically increased in situations of tissue necrosis such as in fulminant hepatic failure, the current results suggest a crucial role for Gc in sequestration and clearance of released cellular actin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.