ArticleInternational journal of molecular sciences2021
P16 and HPV Genotype Significance in HPV-Associated Cervical Cancer-A Large Cohort of Two Tertiary Referral Centers.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Pooled it
- When Immunophenotype Is Not Identity: A Clinicopathological Review of Neuroendocrine Differentiation in Tumors of the Female Genital Tract.Diagnostics (Basel, Switzerland) · 2026Review
- Metastatic Oropharyngeal Squamous Cell Carcinoma to the Colon: A Rare Cause of Acute Lower Gastrointestinal Bleeding.ACG case reports journal · 2026Article
- In Vitro Model Characterizing Carcinogenic Progression of HPV-Positive Oropharyngeal Cancer.Cancers · 2026Article
- Quantification of head and neck cancer patients' anatomical changes during radiotherapy: Toward the prediction of replanning need.Journal of applied clinical medical physics · 2026Article
- Long-Term Survival Outcomes of HPV DNA-Negative Cervical Cancer Compared with HPV DNA-Positive Disease in a Thai Tertiary Cohort.International journal of women's health · 2026Article
- Integrating Biomarkers into Cervical Cancer Screening-Advances in Diagnosis and Risk Prediction: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Squamous cell carcinoma of unknown primary in the pelvis after complete remission following chemoradiotherapy: A case report.World journal of clinical cases · 2025Article
- Clinically Advanced Warty Invasive Squamous Cell Carcinoma of the Cervix with p16 Overexpression-Case Study and Literature Review.Reports (MDPI) · 2025Article
- Article
- A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16JID innovations : skin science from molecules to population health · 2025Article
- Rates of p16 and p53 expression in head and neck cutaneous squamous cell carcinoma vary according to human papillomavirus status.World journal of clinical cases · 2025Article
- Expanding the Horizons of ctHPVDNA Testing.Head and neck pathology · 2025Article
- Genetic analysis of HPV-16 L1 gene mutations and computational screening of therapeutic inhibitors for cervical cancer treatment.Medical oncology (Northwood, London, England) · 2025Article
- Correlation and prognosis analysis of human papillomavirus infection and P16 expression in oral and oropharyngeal squamous cell carcinomas.Scientific reports · 2025Article
- P16 and CD44 as Biomarkers for Predicting the Progression of Immature Polypoid Squamous Metaplasia of the Cervix.Cureus · 2025Article
- ATP13A2 as a prognostic biomarker and its correlation with immune infiltration in cervical cancer: A retrospective study.Journal of cellular and molecular medicine · 2025Article
- Endocervical adenocarcinomas and HPV genotyping in an HIV endemic milieu - a retrospective study.BMC women's health · 2025Article
- The promise of PD1/PDL1 targeted immunotherapy in locally advanced cervical cancer: a game-changer for patients outcome?Frontiers in immunology · 2025Review
- Transcriptionally Active Human Papillomavirus in Male Genital Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma.JID innovations : skin science from molecules to population health · 2025Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of p16 is a good surrogate of human papillomavirus (HPV) infection in HPV-associated cancers. The significance of p16 expression, HPV genotype and genera in the outcome of patients with HPV-associated cervical cancer (CC) is unclear. Our aim is to ascertain the prognostic significance of these factors. Data from 348 patients (median age: 47.5 years old) with CC, diagnosed in two referral centers, were retrospectively collected. Advanced disease (FIGO2018 IB2-IV) was present in 68% of patients. A single HPV genotype was identified in 82.8% of patients. The most common HPVs were HPV16 (69%) and HPV18 (14%). HPV genera reflected this distribution. HPV16 tumors presented at an earlier stage. P16 was negative in 18 cases (5.2%), 83.3% of which were squamous cell carcinomas. These cases occurred in older patients who tended to have advanced disease. In the univariate analysis, HPV16 (HR: 0.58;
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