Evidence map›Paper›PMID 33668990›Full record

ArticleJournal of fungi (Basel, Switzerland)2021

Disseminated Mucormycosis in Immunocompromised Children: Are New Antifungal Agents Making a Difference? A Multicenter Retrospective Study.

Sarah Elitzur, Salvador Fischer, Nira Arad-Cohen, Assaf Barg, Miriam Ben-Harosh, Dana Danino, Ronit Elhasid, Aharon Gefen, Gil Gilad, Itzhak Levy and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Sarah ElitzurThe Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petah Tikva 4920235, Israel.
Salvador FischerThe Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petah Tikva 4920235, Israel.
Nira Arad-CohenPediatric Hematology-Oncology Department, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa 3109601, Israel.
Assaf BargSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Miriam Ben-HaroshDepartment of Pediatric Hematology-Oncology, Soroka Medical Center, Ben Gurion University, Beer Sheva 8489501, Israel.
Dana DaninoPediatric Infectious Disease Unit, Soroka Medical Center, Ben Gurion University, Beer Sheva 8489501, Israel.
Ronit ElhasidSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Aharon GefenPediatric Hematology-Oncology Department, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa 3109601, Israel.
Gil GiladThe Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petah Tikva 4920235, Israel.
Itzhak LevySackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Yael Shachor-MeyouhasRappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Sigal WeinrebPediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 9112000, Israel.
Shai IzraeliThe Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petah Tikva 4920235, Israel.
Shlomit Barzilai-BirenboimThe Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petah Tikva 4920235, Israel.ORCID 0000-0002-3994-0556
Tel Aviv University · ILTechnion – Israel Institute of Technology · ILBen-Gurion University of the Negev · ILHadassah Medical Center · ILSoroka Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMucormycosis is a life-threatening infection with a tendency for angioinvasion that may lead to progressive dissemination. Disseminated mucormycosis, defined as the involvement of two or more non-contiguous sites, is rare in children, and data concerning its management and outcome are scarce. The aim of this study was to assess the contemporary management strategies and outcomes of disseminated mucormycosis in the pediatric population.

methodsWe conducted a retrospective search in six large tertiary medical centers for all cases of disseminated mucormycosis that occurred between 2009-2020 in patients aged 1-20 years.

resultsTwelve cases were identified. Underlying conditions included hematological malignancies (

conclusionsDisseminated mucormycosis is a life-threatening and often fatal disease, and improved diagnostic and therapeutic strategies are needed. Nevertheless, in this population-based study, five patients (42%) were salvaged through combined liposomal amphotericin/triazole treatment and extensive surgical interventions.

Indexed as

antifungal agentschildrenimmunocompromisedinvasive fungal infectionsleukemiamucormycosispediatric hematology oncology

Identifiers

PMID33668990
PMCPMC7996519
OpenAlexW3132005016

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.