Evidence map›Paper›PMID 33668930›Full record

ArticleInternational journal of molecular sciences2021

The RNAi Mechanism Regulates a New Exonuclease Gene Involved in the Virulence of Mucorales.

Carlos Pérez-Arques, María Isabel Navarro-Mendoza, Laura Murcia, Eusebio Navarro, Victoriano Garre, Francisco Esteban Nicolás

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Molecular mechanisms that govern infection and antifungal resistance in Mucorales.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  3. Article
  4. Journal of fungi (Basel, Switzerland) · 2023
    Review
  5. Heterochromatin and RNAi act independently to ensure genome stability in Mucorales human fungal pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carlos Pérez-ArquesDepartmento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.
María Isabel Navarro-MendozaDepartmento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0002-3560-6155
Laura MurciaDepartmento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0001-7768-0989
Eusebio NavarroDepartmento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0002-3091-4378
Victoriano GarreDepartmento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0001-7605-1726
Francisco Esteban NicolásDepartmento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0003-3762-5971
Universidad de Murcia · ES

Funding

FEDER, and RYC-2014-15844 2014-15844Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia, Spain 19339/PI/14Ministerio de Economía y Competitividad BFU2015-65501-P
6 · The paper itself

Abstract

Mucormycosis is a lethal disease caused by Mucorales, which are emerging as human causes that explain the high mortality for this disease. Consequently, the research community is searching for virulence determinants that could be repurposed as targets to develop new treatments against mucormycosis. Our work explores an RNA interference (RNAi)-based approach to find targets involved in the virulence of Mucorales. A transcriptomewide analysis compared sRNAs and their target mRNAs in two

Indexed as

RNA InterferenceExonucleasesGene Expression Regulation, FungalGenes, FungalMucoralesMutationRNA, FungalTranscriptomeVirulenceExonucleasesRNA, FungalexonucleaseMucoralesMucor lusitanicusmucormycosisRNAivirulencevirulence factorwex1 gene

Identifiers

PMID33668930
PMCPMC7956310
OpenAlexW3130924485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.