Evidence map›Paper›PMID 33668922›Full record

ReviewCells2021

Thinking Outside the Bug: Targeting Outer Membrane Proteins for

Megan E Grund, Jeon Choi Soo, Christopher K Cote, Rita Berisio, Slawomir Lukomski

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Colony morphotype variation inJournal of bacteriology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Vaccines · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Megan E GrundDepartment of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Jeon Choi SooDepartment of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Christopher K CoteBacteriology Division, The United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD 21702, USA.
Rita BerisioInstitute of Biostructures and Bioimaging, National Research Council (CNR-IBB), 80145 Naples, Italy.
Slawomir LukomskiDepartment of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
West Virginia University · USNational Research Council · ITUnited States Army Medical Research Institute of Infectious Diseases · US

Funding

MIUR PRIN project GA 2017SFBFER, 2019-202.1Vaccine Development Center Research Challenge Grant HEPC.dsr.18.6
6 · The paper itself

Abstract

Increasing antimicrobial resistance due to misuse and overuse of antimicrobials, as well as a lack of new and innovative antibiotics in development has become an alarming global threat. Preventative therapeutics, like vaccines, are combative measures that aim to stop infections at the source, thereby decreasing the overall use of antibiotics. Infections due to Gram-negative pathogens pose a significant treatment challenge because of substantial multidrug resistance that is acquired and spread throughout the bacterial population.

Indexed as

Amino Acid SequenceAnimalsAntigens, BacterialBacterial VaccinesBurkholderiaHumansMembrane ProteinsModels, BiologicalAntigens, BacterialBacterial VaccinesMembrane ProteinsBucl8Burkholderiacystic fibrosisglandersmelioidosisOmp85OmpAOmpWouter membrane proteinsvaccine

Identifiers

PMID33668922
PMCPMC7996558
OpenAlexW3132037559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.