Evidence map›Paper›PMID 33668849›Full record

Trial reportNutrients2021

Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI.

Shweta Khandelwal, Dimple Kondal, Monica Chaudhry, Kamal Patil, Mallaiah Kenchaveeraiah Swamy, Gangubai Pujeri, Swati Babu Mane, Yashaswi Kudachi, Ruby Gupta, Usha Ramakrishnan and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03072277 (Maternal Docosa-Hexaenoic Acid), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03072277 phase3completednot on this map

Maternal Docosa-Hexaenoic Acid (DHA) Supplementation and Offspring Neurodevelopment in India (DHANI-2)

TypeinterventionalSponsorPublic Health Foundation of IndiaRan2015 to 2020Enrolled957ConditionsPregnancyArmsDocosa Hexaenoic Acid (DHA), Placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. DHA supplementation and pregnancy complications.Journal of translational medicine · 2023
    Review
  4. Promising Sources of Plant-Derived Polyunsaturated Fatty Acids: A Narrative Review.International journal of environmental research and public health · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Shweta KhandelwalPublic Health Foundation of India, Gurugram 122003, India.ORCID 0000-0002-7208-670X
Dimple KondalPublic Health Foundation of India, Gurugram 122003, India.
Monica ChaudhryPublic Health Foundation of India, Gurugram 122003, India.
Kamal PatilDepartment of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 590010, India.
Mallaiah Kenchaveeraiah SwamyDepartment of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 590010, India.
Gangubai PujeriDepartment of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 590010, India.
Swati Babu ManeDepartment of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 590010, India.
Yashaswi KudachiDepartment of Obstetrics and Gynaecology, KAHER's J. N. Medical College, Belagavi 590010, India.
Ruby GuptaPublic Health Foundation of India, Gurugram 122003, India.
Usha RamakrishnanHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Aryeh D SteinHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-1138-6458
Dorairaj PrabhakaranPublic Health Foundation of India, Gurugram 122003, India.
Nikhil TandonAll India Institute of Medical Sciences, New Delhi 110016, India.
KLE University · INCentre for Chronic Disease Control · INEmory University · USAll India Institute of Medical Sciences · INPublic Health Foundation of India · IN

Funding

The Wellcome Trust DBT India Alliance IA/CPHE/14/1/501498
6 · The paper itself

Abstract

Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14-20 weeks' gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA;

Indexed as

AnthropometryChild DevelopmentDietary SupplementsPrenatal Nutritional Physiological PhenomenaAdultBirth WeightDocosahexaenoic AcidsDouble-Blind MethodFemaleHumansIndiaInfant, NewbornPregnancyYoung AdultDocosahexaenoic Acidsanthropometrybirth lengthbirth weightdocosahexaenoic acid (DHA)head circumferencelong chain omega-3 fatty acidsmaternal supplementationpregnancy outcomes

Identifiers

PMID33668849
PMCPMC7996222
OpenAlexW3132472242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.