ReviewToxics2021
Heavy Metals and Pesticides Toxicity in Agricultural Soil and Plants: Ecological Risks and Human Health Implications.
Review in Toxics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 405 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
405 citing papers in PubMed, 4 syntheses or guidelines pooled it, 2,076 citations in OpenAlex.
- Fluoride as a Modifier of Metallome Homeostasis: A Systematic Review of Animal Studies.Basic & clinical pharmacology & toxicology · 2026Pooled it
- Toxic Metal in Plant-Based Therapeutics: Contamination Pathways, Oxidative Stress Induction, and Onset of Disease.TheScientificWorldJournal · 2026Pooled it
- Systematic Review on Neurotoxic Implications of Lead-Induced Gene Expression Alterations in the Etiology of Alzheimer's Disease.Cellular and molecular neurobiology · 2025Pooled it
- Prevalence, characteristics, and treatment outcomes of epilepsy in Nigeria: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Exogenous pipecolic acid ameliorates lead-induced phytotoxicity in chili (Plant signaling & behavior · 2026Article
- Association between early-life farming exposure and Alzheimer's disease neuropathological burden.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Integrated nutrient and plant growth regulator management improves cadmium phytoextraction in Ricinus communis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Salidroside in heavy metal toxicity: a mechanistic review of antioxidant, anti-inflammatory, and anti-apoptotic pathways.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Mineral Accumulation and Physiological Responses of Two Halophytes,Plants (Basel, Switzerland) · 2026Article
- Migration-driven exposome reconfiguration: a predictive, preventive and personalized medicine perspective on cardiometabolic risk.The EPMA journal · 2026Review
- Biological applications and future perspectives of bioactive compounds as pig feed additives.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Seasonal Dynamics of Trace Element Contamination in Chashma Lake: Distribution in Water and Sediment, Bioaccumulation in Labeo rohita and Wallago attu, and Human Health Risk Assessment.Biological trace element research · 2026Article
- Heavy metals and pesticides in medicinal plants: environmental sources, plant responses, and human health risk assessment.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Photolytic Hydrophosphination: Insights Into Catalyzed and Uncatalyzed Processes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- An Investigation of Heavy Metal Accumulation in Liver and Kidney Tissues of the European Hare (Toxics · 2026Article
- Impacts of pollution on the soil microbiome.Nature reviews. Microbiology · 2026Review
- Metal-Organic Frameworks in Food Biotechnology: Opportunities, Challenges, and Future Perspectives for Probiotic Delivery, Precision Fermentation, and Circular Food Systems.Nanomaterials (Basel, Switzerland) · 2026Review
- Exogenous sodium nitroprusside alleviates cadmium toxicity in Solanum nigrum via antioxidant activation, metal redistribution, and gene expression modulation.Protoplasma · 2026Article
- Recent Developments in Graphene-Based Adsorbents for Environmental Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- Harnessing biostimulants to alleviate potentially toxic element stress in vegetable crops.Planta · 2026Review
345 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Environmental problems have always received immense attention from scientists. Toxicants pollution is a critical environmental concern that has posed serious threats to human health and agricultural production. Heavy metals and pesticides are top of the list of environmental toxicants endangering nature. This review focuses on the toxic effect of heavy metals (cadmium (Cd), lead (Pb), copper (Cu), and zinc (Zn)) and pesticides (insecticides, herbicides, and fungicides) adversely influencing the agricultural ecosystem (plant and soil) and human health. Furthermore, heavy metals accumulation and pesticide residues in soils and plants have been discussed in detail. In addition, the characteristics of contaminated soil and plant physiological parameters have been reviewed. Moreover, human diseases caused by exposure to heavy metals and pesticides were also reported. The bioaccumulation, mechanism of action, and transmission pathways of both heavy metals and pesticides are emphasized. In addition, the bioavailability in soil and plant uptake of these contaminants has also been considered. Meanwhile, the synergistic and antagonistic interactions between heavy metals and pesticides and their combined toxic effects have been discussed. Previous relevant studies are included to cover all aspects of this review. The information in this review provides deep insights into the understanding of environmental toxicants and their hazardous effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.