Evidence map›Paper›PMID 33668698›Full record

ReviewVaccines2021

Development of Pandemic Vaccines: ERVEBO Case Study.

Jayanthi Wolf, Risat Jannat, Sheri Dubey, Sean Troth, Matthew T Onorato, Beth-Ann Coller, Mary E Hanson, Jakub K Simon

Abstract readReview
In one paragraph

Review in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jayanthi WolfRegulatory Affairs, Merck & Co. Inc., Kenilworth, NJ 07033, USA.
Risat JannatGlobal Vaccines & Biologics Commercialization, Merck & Co. Inc., Kenilworth, NJ 07033, USA.
Sheri DubeyPharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co. Inc., Kenilworth, NJ 07033, USA.
Sean TrothDepartment of Safety Assessment and Laboratory Animal Resources, Merck & Co. Inc., Kenilworth, NJ 07033, USA.ORCID 0000-0002-4696-5129
Matthew T OnoratoGlobal Clinical Trial Operations, Vaccines, Merck & Co. Inc., Kenilworth, NJ 07033, USA.
Beth-Ann CollerGlobal Clinical Development, Vaccines, Merck & Co. Inc., Kenilworth, NJ 07033, USA.
Mary E HansonGlobal Scientific & Medical Publications, Merck & Co. Inc., Kenilworth, NJ 07033, USA.
Jakub K SimonGlobal Clinical Development, Vaccines, Merck & Co. Inc., Kenilworth, NJ 07033, USA.

Funding

Merck n/a
6 · The paper itself

Abstract

Preventative vaccines are considered one of the most cost-effective and efficient means to contain outbreaks and prevent pandemics. However, the requirements to gain licensure and manufacture a vaccine for human use are complex, costly, and time-consuming. The 2013-2016 Ebola virus disease (EVD) outbreak was the largest EVD outbreak to date and the third Public Health Emergency of International Concern in history, so to prevent a pandemic, numerous partners from the public and private sectors combined efforts and resources to develop an investigational

Indexed as

Ebolavirus vaccineregulatory strategyrVSVΔG-ZEBOV-GPvaccine developmentvaccine manufacturing

Identifiers

PMID33668698
PMCPMC7996233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.