ReviewNutrients2021
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06995586 (The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.), which is not on this map. Cited by 227 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.
Who cites it
227 citing papers in PubMed, 4 syntheses or guidelines pooled it, 490 citations in OpenAlex.
- Clinical benefits and risks of high-dose intravenous vitamin C: a systematic review.Journal of medicine and life · 2026Pooled it
- Long-term prevalence of vitamin deficiencies after bariatric surgery: a meta-analysis.Langenbeck's archives of surgery · 2024Pooled it
- A meta-analysis of the effects of vitamin C supplementation for pregnant smokers on the pulmonary function of their offspring.BMC pregnancy and childbirth · 2024Pooled it
- The role of vitamin C in the prevention of pancreatic cancer: a systematic-review.Frontiers in nutrition · 2024Pooled it
- Metabolic and Neuroenergetic Effects of Intranasal Vitamin C Application in the Human Brain.Nutrients · 2025Trial
- Trial
- Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial.European journal of nutrition · 2025Trial
- Comparative efficacy of platelet-rich plasma (PRP) injection versus PRP combined with vitamin C injection for partial-thickness rotator cuff tears: a randomized controlled trial.Journal of orthopaedic surgery and research · 2024Trial
- Trial
- A liposome-hydrogel composite ameliorates UVB-induced mouse skin photoaging through integrated antioxidant and extracellular matrix remodeling pathways.Drug delivery · 2026Article
- Relationship Between Hypovitaminosis C, Obesity, and Features of Metabolic Syndrome-A Narrative Review.Nutrition reviews · 2026Review
- Ascorbate-driven quinone redox cycling as a pro-oxidant anticancer strategy.Redox biology · 2026Review
- Impaired healing following implant placement surgery: A case report of a modern-day manifestation of scurvy.Clinical advances in periodontics · 2026Article
- The Illusion of Simplicity: The Dramatic Failure of Koopmans' Theorem for Antioxidants in Solvents-The Ascorbic Acid Paradigm.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Article
- Nonlinear association between composite dietary antioxidant index and irritable bowel syndrome: insights from UK Biobank.BMC public health · 2026Article
- Ascorbic Acid for Major Depressive Disorder Treated With Modified Electroconvulsive Therapy: A Randomized Controlled Trial Protocol.Alpha psychiatry · 2026Article
- Potential Antidote Against Lead Toxicity-A Review.International journal of molecular sciences · 2026Review
- Association of serum vitamin D and serum vitamin C with the risk of melanoma among adults in the United States: a cross-sectional analysis of 2003-2006 and 2017-2018 NHANES data.Journal of clinical biochemistry and nutrition · 2026Article
- Valorization of broccoli waste: Unlocking its potential as a functional food ingredient for sustainable nutrition.Journal of advanced research · 2026Review
167 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence-scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.