Evidence map›Paper›PMID 33668602›Full record

ArticleJournal of clinical medicine2021

Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification.

Gianfranco Favia, Angela Tempesta, Giuseppe Barile, Nicola Brienza, Saverio Capodiferro, Maria Concetta Vestito, Lucilla Crudele, Vito Procacci, Giuseppe Ingravallo, Eugenio Maiorano and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 11 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 11 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review.Journal of stomatology, oral and maxillofacial surgery · 2022
    Pooled it
  3. Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  8. Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  9. Oral mucosal lesions in patients with COVID-19: a systematic review.The British journal of oral & maxillofacial surgery · 2021
    Pooled it
  10. A Review of Prolonged Post-COVID-19 Symptoms and Their Implications on Dental Management.International journal of environmental research and public health · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Gianfranco FaviaOdontostomatology Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Angela TempestaOdontostomatology Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Giuseppe BarileOdontostomatology Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Nicola BrienzaCovid-19 Intensive Care Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Saverio CapodiferroOdontostomatology Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.ORCID 0000-0002-9819-6229
Maria Concetta VestitoCovid-19 Intensive Care Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Lucilla CrudeleCovid-19 Emergency Unit, Department of Emergency and Urgency, University Hospital Policlinic of Bari, 70124 Bari, Italy.
Vito ProcacciCovid-19 Emergency Unit, Department of Emergency and Urgency, University Hospital Policlinic of Bari, 70124 Bari, Italy.
Giuseppe IngravalloPathological Anatomy Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-4792-3545
Eugenio MaioranoPathological Anatomy Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-0472-5338
Luisa LimongelliOdontostomatology Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.ORCID 0000-0001-5246-1253
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to report on the oral lesions detected in 123 patients diagnosed at the University Hospital of Bari from October 2020 to December 2020, focusing on the correlation of clinical and pathological features in order to purpose a new classification.

methodsGeneral and specialistic anamnesis were achieved and oral examination was performed. The following data were collected: age/gender, general symptoms and form of Covid-19, presence and features of taste disorders, day of appearance of the oral lesions, type and features of oral lesions and day of beginning of therapies. If ulcerative lesions did not heal, biopsy was performed.

resultsMany types of oral lesions were found and classified into four groups considering the timing of appearance and the start of the therapies. Early lesions in the initial stages of Covid-19 before the start of therapies was observed in 65.9% of the patients. In the histopathological analysis of four early lesions, thrombosis of small and middle size vessels was always noticed with necrosis of superficial tissues.

conclusionThe presence of oral lesions in early stages of Covid-19 could represent an initial sign of peripheral thrombosis, a warning sign of possible evolution to severe illness. This suggests that anticoagulant therapies should start as soon as possible.

Indexed as

classificationCovid-19oral lesionsoral ulcers

Identifiers

PMID33668602
PMCPMC7918830
OpenAlexW3133293628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.