Evidence map›Paper›PMID 33668537›Full record

ReviewJournal of clinical medicine2021

Optical Coherence Tomography Angiography of the Choriocapillaris in Age-Related Macular Degeneration.

Jackson Scharf, Giulia Corradetti, Federico Corvi, SriniVas Sadda, David Sarraf

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025
    Article
  3. New insights in pathogenic mechanism of hydroxychloroquine-induced ocular toxicity through choroidal imaging analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jackson ScharfVagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Giulia CorradettiDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.
Federico CorviDoheny Eye Institute, University of California, Los Angeles, CA 90033, USA.ORCID 0000-0002-2661-5500
SriniVas SaddaDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.
David SarrafDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USColumbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of optical coherence tomography angiography (OCTA) has allowed for remarkable advancements in our understanding of the role of the choriocapillaris in age-related macular degeneration (AMD). As a relatively new imaging modality, techniques to analyze and quantify choriocapillaris images are still evolving. Quantification of the choriocapillaris requires careful consideration of many factors, including the type of OCTA device, segmentation of the choriocapillaris slab, image processing techniques, and thresholding method. OCTA imaging shows that the choriocapillaris is impaired in intermediate non-neovascular AMD, and the severity of impairment may predict the advancement of disease. In advanced atrophic AMD, the choriocapillaris is severely impaired underneath the area of geographic atrophy, and the level of impairment surrounding the lesion predicts the rate of atrophy enlargement. Macular neovascularization can be readily identified and classified using OCTA, but it is still unclear if neovascularization features with OCTA can predict the lesion's level of activity. The choriocapillaris surrounding macular neovascularization is impaired while the more peripheral choriocapillaris is spared, implying that choriocapillaris disruption may drive neovascularization growth. With continued innovation in OCTA image acquisition and analysis methods, advancement in clinical applications and pathophysiologic discoveries in AMD are set to follow.

Indexed as

age-related macular degenerationchoriocapillarischoriocapillaris quantificationflow deficitmacular neovascularizationOCT-Aoptical coherence tomography angiographyretinal imaging

Identifiers

PMID33668537
PMCPMC7918036
OpenAlexW3131465502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.