Evidence map›Paper›PMID 33668461›Full record

ArticleInternational journal of environmental research and public health2021

Stress and Cardiometabolic Disease Risk for Indigenous Populations throughout the Lifespan.

Melissa E Lewis, Hannah I Volpert-Esmond, Jason F Deen, Elizabeth Modde, Donald Warne

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  12. Scoping Review of the Environmental and Human Health Effects of Rural Alaska Landfills.International journal of environmental research and public health · 2025
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  19. Co-Designing Research for Sustainable Food Systems and Diets with Aboriginal Communities: A Study Protocol.International journal of environmental research and public health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Melissa E LewisDepartment of Family and Community Medicine, School of Medicine, University of Missouri, Columbia, MO 65212, USA.ORCID 0000-0002-6999-5865
Hannah I Volpert-EsmondPsychology Department, University of Texas, El Paso, TX 79902, USA.
Jason F DeenDepartment of Pediatrics, University of Washington, Seattle, WA 98195, USA.
Elizabeth ModdeDepartment of Family and Community Medicine, School of Medicine, University of Missouri, Columbia, MO 65212, USA.
Donald WarneFamily & Community Medicine Department, University of North Dakota, Grand Forks, ND 58202, USA.ORCID 0000-0002-2977-5286
University of Missouri · USThe University of Texas at El Paso · USUniversity of North Dakota · USUniversity of Washington · US

Funding

Washington University Center for Diabetes Translation Research P30DK092950 · NIDDK · WASHINGTON UNIVERSITY · PI Ross C Brownson, Debra Haire-Joshu · 2011 to 2026
$11.7M
Adaptation and implementation of a Cherokee-based participatory research project to reduce CVD riskK01HL142944 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LEWIS, MELISSA · 2020 to 2024
$666k
NHLBI NIH HHS K01 HL142944NHLBI NIH HHS K01HL142944NIDDK NIH HHS P30 DK092950
6 · The paper itself

Abstract

backgroundIndigenous people experience the greatest cardiometabolic disease disparity in the Unites States, yet high cardiometabolic disease risk factors do not fully explain the extent of the cardiometabolic disease disparity for Indigenous people. Stress, trauma, and racism occur at high rates within Indigenous communities and have not been well explored as significant contributors to cardiometabolic disease disparities despite emerging literature, and therefore will be described here.

methodsThis descriptive study explores the relationship between cardiometabolic disease risks and Indigenous-specific stressors (e.g., early childhood stress and trauma, adulthood stress and trauma, and historical and intergenerational trauma) using current literature. Indigenous-specific protective factors against cardiometabolic disease are also reviewed.

resultsIncreasing research indicates that there is a relationship between Indigenous-specific stressful and traumatic life experiences and increased cardiometabolic disease risk. Mental health and psychophysiology play an important role in this relationship. Effective interventions to reduce cardiometabolic disease risk in Indigenous communities focus on ameliorating the negative effects of these stressors through the use of culturally specific health behaviors and activities.

conclusionsThere is increasing evidence that cultural connection and enculturation are protective factors for cardiometabolic disease, and may be galvanized through Indigenous-led training, research, and policy change.

Indexed as

Cardiovascular DiseasesRacismAdultChildChild, PreschoolHumansIndigenous PeoplesLongevityPopulation Groupsadverse childhood experiencescardiometabolic diseasehistorical traumaIndigenous populationstress

Identifiers

PMID33668461
PMCPMC7918141
OpenAlexW3129362370

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.