Evidence map›Paper›PMID 33668457›Full record

ArticleCells2021

Gut Microbiome Profiles and Associated Metabolic Pathways in HIV-Infected Treatment-Naïve Patients.

Wellinton M do Nascimento, Aline Machiavelli, Luiz G E Ferreira, Luisa Cruz Silveira, Suwellen S D de Azevedo, Gonzalo Bello, Daniel P Smith, Melissa P Mezzari, Joseph F Petrosino, Rubens Tadeu Delgado Duarte and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  3. Review
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  10. The contemporary immunoassays for HIV diagnosis: a concise overview.Asian biomedicine : research, reviews and news · 2023
    Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Wellinton M do NascimentoLaboratório de Imunologia Aplicada, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Campus Universitário da Trindade, Florianópolis, SC 88034-040, Brazil.
Aline MachiavelliLaboratório de Imunologia Aplicada, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Campus Universitário da Trindade, Florianópolis, SC 88034-040, Brazil.ORCID 0000-0002-5804-3826
Luiz G E FerreiraHospital Regional Homero de Miranda Gomes, Rua Adolfo Donato da Silva, s/n, São José, SC 88103-901, Brazil.
Luisa Cruz SilveiraLaboratório de Imunologia Aplicada, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Campus Universitário da Trindade, Florianópolis, SC 88034-040, Brazil.ORCID 0000-0001-5959-7217
Suwellen S D de AzevedoLaboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil, 4365, Rio de Janeiro, RJ 21045-900, Brazil.ORCID 0000-0001-6681-0987
Gonzalo BelloLaboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil, 4365, Rio de Janeiro, RJ 21045-900, Brazil.
Daniel P SmithAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-2479-2044
Melissa P MezzariAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0003-0610-9720
Joseph F PetrosinoAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Rubens Tadeu Delgado DuarteLaboratório de Ecologia Molecular e Extremófilos, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Campus Universitário da Trindade, Florianópolis, SC 88034-040, Brazil.
Carlos R Zárate-BladésLaboratório de Imunorregulação, iREG, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Campus Universitário da Trindade, Florianópolis, SC 88034-040, Brazil.ORCID 0000-0002-7728-7869
Aguinaldo R PintoLaboratório de Imunologia Aplicada, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Campus Universitário da Trindade, Florianópolis, SC 88034-040, Brazil.ORCID 0000-0002-0991-8876
Universidade Federal de Santa Catarina · BRBaylor College of Medicine · USFundação Oswaldo Cruz · BRHospital Regional de São José Dr. Homero de Miranda Gomes · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The normal composition of the intestinal microbiota is a key factor for maintaining healthy homeostasis, and accordingly, dysbiosis is well known to be present in HIV-1 patients. This article investigates the gut microbiota profile of antiretroviral therapy-naive HIV-1 patients and healthy donors living in Latin America in a cohort of 13 HIV positive patients (six elite controllers, EC, and seven non-controllers, NC) and nine healthy donors (HD). Microbiota compositions in stool samples were determined by sequencing the V3-V4 region of the bacterial 16S rRNA, and functional prediction was inferred using PICRUSt. Several taxa were enriched in EC compared to NC or HD groups, including

Indexed as

Gastrointestinal MicrobiomeMetabolic Networks and PathwaysAdultBacteriaDiscriminant AnalysisFecesFemaleHIV-1HIV InfectionsHumansMiddle Agedhuman immunodeficiency virusmetabolismmicrobiomesexual orientationvirus subtypes

Identifiers

PMID33668457
PMCPMC7917727
OpenAlexW3131358815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.