Evidence map›Paper›PMID 33668443›Full record

ArticleCancers2021

Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors.

Katarina Letkovska, Pavel Babal, Zuzana Cierna, Silvia Schmidtova, Veronika Liskova, Katarína Kalavska, Vera Miskovska, Samuel Horak, Katarina Rejlekova, Michal Chovanec and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Hurdles of Sperm Success: Exploring the Role of DNases.International journal of molecular sciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Katarina LetkovskaDepartment of Pathology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia.
Pavel BabalDepartment of Pathology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia.ORCID 0000-0001-8170-1850
Zuzana CiernaDepartment of Pathology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia.
Silvia SchmidtovaTranslational Research Unit, 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovakia.ORCID 0000-0003-4537-2062
Veronika LiskovaInstitute of Clinical and Translational Research, Biomedical Research Center of the Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.
Katarína KalavskaTranslational Research Unit, 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovakia.
Vera Miskovska1st Department of Oncology, Comenius University, Faculty of Medicine, St. Elisabeth Cancer Institute, 812 50 Bratislava, Slovakia.
Samuel HorakDepartment of Pathology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia.
Katarina Rejlekova2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovakia.
Michal Chovanec2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovakia.
Jozef Mardiak2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovakia.
Pavel JanegaDepartment of Pathology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia.ORCID 0000-0003-0036-7286
Michal MegoTranslational Research Unit, 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, 833 10 Bratislava, Slovakia.ORCID 0000-0002-6511-6827
Comenius University Bratislava · SKCancer Research Institute of the Slovak Academy of Sciences · SKBiomedical Research Center of the Slovak Academy of Sciences · SKUniversity of Trnava · SK

Funding

Ministry of Health MZ SR 2018/39-LFUK-13the Slovak Research and Development Agency APVV-15-0086 and APVV-19-0411the VEGA Grant Agency of the Slovak Republic VEGA 1/0043/18
6 · The paper itself

Abstract

Apoptosis is a strictly regulated process essential for preservation of tissue homeostasis. This study aimed to evaluate expression of apoptosis inducing factor (AIF) in testicular germ cell tumors (GCTs) and to correlate expression patterns with clinicopathological variables. Formalin-fixed and paraffin-embedded specimens of non-neoplastic testicular tissue and GCTs obtained from 216 patients were included in the study. AIF expression was detected by immunohistochemistry, scored by the multiplicative quickscore method (QS). Normal testicular tissue exhibits higher cytoplasmic granular expression of AIF compared to GCTs (mean QS = 12.77 vs. 4.80,

Indexed as

apoptosisapoptosis inducing factorprognosistesticular germ cell tumors

Identifiers

PMID33668443
PMCPMC7917670
OpenAlexW3130175006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.