ArticleMicroorganisms2021
The Global Burden of Meningitis in Children: Challenges with Interpreting Global Health Estimates.
Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Global, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.The Lancet. Neurology · 2023Pooled it
- Prevalence and Associated Factor of Meningococcal Carriers of Indonesian Umrah Pilgrims.Journal of epidemiology and global health · 2026Article
- Global, regional, and national burden of pathogen-attributable infectious diseases in children by age and sex, 1990-2021: a systematic analysis.Infection · 2026Article
- Trends in Meningitis Burden and Projections to 2040: A Secondary Analysis of the Global Burden of Disease Study 2023.Health science reports · 2026Article
- Impact of the BioFire FilmArray Meningitis-Encephalitis Panel on Management of Suspected Paediatric Central Nervous System Infections: A Single-Centre Retrospective Cohort Study.Journal of paediatrics and child health · 2026Article
- Non-invasive meningitis screening in neonates and infants: multicentre international study.Pediatric research · 2026Article
- Clinical features and risk factors of neonatal late-onset sepsis complicated by purulent meningitis.Frontiers in pediatrics · 2026Article
- Article
- The evolving burden of childhood meningitis in low- and middle-income countries, 1990-2021: a decomposition and frontier analysis.European journal of pediatrics · 2025Article
- Pediatric Coccidioidal Meningitis: A Systematic Review and Proportional Synthesis of Cases Reported in the Fluconazole Era (2000-2025).Journal of fungi (Basel, Switzerland) · 2025Review
- Establishment of a risk prediction model for hydrocephalus complicated by neonatal bacterial meningitis.BMC infectious diseases · 2025Article
- Healthcare and productivity loss costs in young adults after bacterial meningitis: a cross-sectional follow-up study.BMJ paediatrics open · 2025Article
- Article
- Etiologies and comorbidities of meningitis deaths in children under 5 years in high-mortality settings: Insights from the CHAMPS Network in the post-pneumococcal vaccine era.The Journal of infection · 2024Observational
- Self-Reported Executive Functioning in Young Adult Survivors of Childhood Bacterial Meningitis.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Article
- Why do central nervous system barriers host a diverse immune landscape?Trends in immunology · 2024Review
- Prognostic value of cranial ultrasound findings in infants aged <90 days with bacterial meningitis: a single-centre retrospective cohort study.BMJ paediatrics open · 2024Article
- Review
- Diagnostic status and epidemiological characteristics of community-acquired bacterial meningitis in children from 2019 to 2020: a multicenter retrospective study.BMC pediatrics · 2024Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
The World Health Organization (WHO) has developed a global roadmap to defeat meningitis by 2030. To advocate for and track progress of the roadmap, the burden of meningitis as a syndrome and by pathogen must be accurately defined. Three major global health models estimating meningitis mortality as a syndrome and/or by causative pathogen were identified and compared for the baseline year 2015. Two models, (1) the WHO and the Johns Hopkins Bloomberg School of Public Health's Maternal and Child Epidemiology Estimation (MCEE) group's Child Mortality Estimation (WHO-MCEE) and (2) the Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease Study (GBD 2017), identified meningitis, encephalitis and neonatal sepsis, collectively, to be the second and third largest infectious killers of children under five years, respectively. Global meningitis/encephalitis and neonatal sepsis mortality estimates differed more substantially between models than mortality estimates for selected infectious causes of death and all causes of death combined. Estimates at national level and by pathogen also differed markedly between models. Aligning modelled estimates with additional data sources, such as national or sentinel surveillance, could more accurately define the global burden of meningitis and help track progress against the WHO roadmap.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.