Evidence map›Paper›PMID 33668417›Full record

ReviewViruses2021

Adenovirus and the Cornea: More Than Meets the Eye.

Jaya Rajaiya, Amrita Saha, Ashrafali M Ismail, Xiaohong Zhou, Ting Su, James Chodosh

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  11. Innate Immune System Activation, Inflammation and Corneal Wound Healing.International journal of molecular sciences · 2022
    Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jaya RajaiyaMassachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Amrita SahaMassachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Ashrafali M IsmailMassachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.ORCID 0000-0001-8694-7235
Xiaohong ZhouMassachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Ting SuMassachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
James ChodoshMassachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.ORCID 0000-0002-7463-1599
Massachusetts Eye and Ear Infirmary · US

Funding

Immunopathogenesis of Adenovirus KeratitisR01EY013124 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI James Chodosh, Jaya Rajaiya · 2001 to 2026
$10.8M
Novel Mechanisms in Adenoviral Ocular PathogenesisR01EY021558 · NEI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI James Chodosh, Jaya Rajaiya · 2011 to 2026
$7.1M
NEI NIH HHS R01 EY013124NEI NIH HHS R01 EY021558
6 · The paper itself

Abstract

Human adenoviruses cause disease at multiple mucosal sites, including the respiratory, gastrointestinal, and genitourinary tracts, and are common agents of conjunctivitis. One site of infection that has received sparse attention is the cornea, a transparent tissue and the window of the eye. While most adenovirus infections are self-limited, corneal inflammation (keratitis) due to adenovirus can persist or recur for months to years after infection, leading to reduced vision, discomfort, and light sensitivity. Topical corticosteroids effectively suppress late adenovirus keratitis but are associated with vision-threatening side effects. In this short review, we summarize current knowledge on infection of the cornea by adenoviruses, including corneal epithelial cell receptors and determinants of corneal tropism. We briefly discuss mechanisms of stromal keratitis due to adenovirus infection, and review an emerging therapy to mitigate adenovirus corneal infections based on evolving knowledge of corneal epithelial receptor usage.

Indexed as

Adenoviridae InfectionsAdenoviruses, HumanAnimalsCorneaCorneal DiseasesHumansadenovirusepidemic keratoconjunctivitishuman corneal epitheliumviral receptor

Identifiers

PMID33668417
PMCPMC7917768
OpenAlexW3129799950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.