Evidence map›Paper›PMID 33668416›Full record

ArticleToxins2021

Rapid and Efficient Enrichment of Snake Venoms from Human Plasma Using a Strong Cation Exchange Tip Column to Improve Snakebite Diagnosis.

Chien-Chun Liu, Ya-Han Yang, Yung-Chin Hsiao, Po-Jung Wang, Jo-Chuan Liu, Chien-Hsin Liu, Wen-Chin Hsieh, Chih-Chuan Lin, Jau-Song Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Chien-Chun LiuMolecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-2324-7976
Ya-Han YangSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Yung-Chin HsiaoMolecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan.
Po-Jung WangMolecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan.
Jo-Chuan LiuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Chien-Hsin LiuCenter for Research, Diagnostics and Vaccine Development of Centers for Disease Control, Ministry of Health and Welfare, Taipei 10050, Taiwan.
Wen-Chin HsiehCenter for Research, Diagnostics and Vaccine Development of Centers for Disease Control, Ministry of Health and Welfare, Taipei 10050, Taiwan.ORCID 0000-0003-4160-8234
Chih-Chuan LinDepartment of Emergency Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan.ORCID 0000-0001-9613-115X
Jau-Song YuMolecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-4295-983X
Chang Gung University · TWChang Gung Memorial Hospital · TWChang Gung University of Science and Technology · TWMinistry of Health and Welfare · TW

Funding

Chang Gung Memorial Hospital CLRPD1J0012Chang Gung Memorial Hospital CMRPD1H0253Ministry of Education, Taiwan The Featured Areas Research Center Program within the framework of the Higher Education Sprout ProjectMinistry of Science and Technology, Taiwan 109-2320-B-182-009-MY3
6 · The paper itself

Abstract

Snake envenomation is a serious public health issue in many tropical and subtropical countries. Accurate diagnosis and immediate antivenom treatment are critical for effective management. However, the venom concentration in the victims' plasma is usually low, representing one of the bottlenecks in developing clinically applicable assays for venom detection and snakebite diagnosis. In this study, we attempted to develop a simple method for rapid enrichment of venom proteins from human plasma to facilitate detection. Our experiments showed that several major protein components of both

Indexed as

BungarusChromatography, High Pressure LiquidChromatography, Ion ExchangeNaja najaAnimalsBiomarkersBungarotoxinsCation Exchange ResinsElapid VenomsHumansPredictive Value of TestsReproducibility of ResultsReptilian ProteinsSnake BitesTandem Mass SpectrometryTime FactorsBiomarkersBungarotoxinsCation Exchange ResinsElapid VenomsReptilian Proteinsclinical diagnostic assaylateral flow stripsnakebitestrong cation exchange chromatographyvenom

Identifiers

PMID33668416
PMCPMC7917991
OpenAlexW3130587264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.