ReviewAntioxidants (Basel, Switzerland)2021
Mitochondrial Dysfunction and Oxidative Stress Caused by Cryopreservation in Reproductive Cells.
Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
What it found
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Who cites it
120 citing papers in PubMed, 211 citations in OpenAlex.
- Redox-mediated mitochondrial collapse drives intrinsic apoptotic signaling in ELT3 cells response to apigenin.Toxicology reports · 2026Article
- Ecotoxicological and Molecular Profiling of Atrazine in Hydra magnipapillata Model: Disruption of Hippo Signalling and Induction of Oxidative Stress.Journal of applied toxicology : JAT · 2026Article
- Proteomic Profiling of Cryopreservation-Induced Alterations in Rhesus Macaque Sperm.Andrology · 2026Article
- In vitro effects of green tea (Camellia sinensis) aqueous extract on sperm quality: Mitigating oxidative stress and sperm DNA fragmentation in freeze-dried human spermatozoa.Clinical and experimental reproductive medicine · 2026Article
- Sperm DNA fragmentation and its influence on mammalian reproduction.Nature reviews. Urology · 2026Review
- L-Histidine Improves Boar Sperm Quality by Alleviating Oxidative Stress During Preservation at 17 °C.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Post-thaw quality of donkey (Equus asinus) spermatozoa exposed to different concentrations of curcumin with respect to oxidative status and nitric oxide.Veterinary research communications · 2026Review
- Label-Free Monitoring of Cancer-Associated Fibroblast Activation Using NAD(P)H Fluorescence Lifetime Imaging.Chembiochem : a European journal of chemical biology · 2026Article
- Innovative nanotechnology approach using salicylic acid loaded chitosan nanoparticles to improve post-thaw sperm function, reduce apoptosis, and preserve ultrastructure in rams.Tropical animal health and production · 2026Article
- Mitochondria-targeted SkQ1 supplementation enhances post-thaw quality, cryosurvival, and functional competence of rooster spermatozoa.Poultry science · 2026Article
- Idebenone reduces oxidative stress and differentially improves chromatin integrity in dog and cat epididymal spermatozoa after slow freezing and vitrification.Veterinary research communications · 2026Article
- The Ameliorative Effects of Carnosine on the In Vitro Developmental Competence of Bovine Oocytes.Antioxidants (Basel, Switzerland) · 2026Article
- Effects of Kaempferol Supplementation on the Cryopreservation Quality of Semen from Yuansheng Aite Dairy Rams.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Autofluorescence imaging reveals the impact of cryopreservation on T cell metabolism and activation response.Molecular therapy. Advances · 2026Article
- Pyrroloquinoline quinone protects heat-stressed porcine oocytes and improves early embryonic development via maintaining mitochondrial integrity and redox homeostasis.Biology direct · 2026Article
- Targeting Oxidative Stress and Inflammation in Pembrolizumab-Induced Renal Injury: A Comparative Evaluation of the Protective Effects of Flunarizine and Carvacrol in Rats.Biomolecules · 2026Article
- The Association Between the Progressive Motility of Bovine Spermatozoa and the Developmental Morphokinetics of In Vitro-Derived Embryos.Journal of developmental biology · 2026Article
- Melatonin Enhances Glutathione Peroxidase Activity and Improves Antioxidant Defense in Cryopreserved Ovarian Transplants: A Rat Model Study.Antioxidants (Basel, Switzerland) · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell death. Mitochondria produce most ROS, and when levels exceed the antioxidant defenses, oxidative stress (OS) is generated. These changes may eventually impair the electron transport chain, resulting in decreased ATP synthesis, increased ROS production, altered mitochondrial membrane permeability, and disruption of calcium homeostasis. Mitochondria play a key role in the gamete competence to facilitate normal embryo development. However, iatrogenic factors in assisted reproductive technologies (ART) may affect their functional competence, leading to an abnormal reproductive outcome. Cryopreservation, a fundamental technology in ART, may compromise mitochondrial function leading to elevated intracellular OS that decreases sperm and oocytes' competence and the dynamics of fertilization and embryo development. This article aims to review the role played by mitochondria and ROS in sperm and oocyte function and the close, biunivocal relationships between mitochondrial damage and ROS generation during cryopreservation of gametes and gonadal tissues in different species. Based on current literature, we propose tentative hypothesis of mechanisms involved in cryopreservation-associated mitochondrial dysfunction in gametes, and discuss the role played by antioxidants and other agents to retain the competence of cryopreserved reproductive cells and tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.