Evidence map›Paper›PMID 33668290›Full record

ArticleMarine drugs2021

Computational Assessment of Chito-Oligosaccharides Interactions with Plasma Proteins.

Diana Larisa Roman, Vasile Ostafe, Adriana Isvoran

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Diana Larisa RomanDepartment of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timisoara, 300223 Timisoara, Romania.
Vasile OstafeDepartment of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timisoara, 300223 Timisoara, Romania.
Adriana IsvoranDepartment of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timisoara, 300223 Timisoara, Romania.ORCID 0000-0002-3068-2642
West University of Timişoara · RO

Funding

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN3-P3-284
6 · The paper itself

Abstract

It is widely recognized that chitin and chitosan are potential sources of bioactive materials and that their oligosaccharides reveal various biological activities (including antimicrobial) that are correlated with their structures and physicochemical properties. This study uses the molecular docking approach to assess the interactions of small chito-oligosaccharides (MW< 1500 Da) with plasma proteins in order to obtain information regarding their fate of distribution in the human organism. There are favorable interactions of small chito-oligomers with plasma proteins, the interactions with human serum albumin being stronger than those with α-1-acid glycoprotein. The interaction energies increase with increasing the molecular weight, decrease with increasing deacetylation degrees and are reliant on the deacetylation pattern. This study could inform the application of chito-oligosaccharides with varying molecular weights, degrees, and patterns of deacetylation in human health.

Indexed as

Molecular Docking SimulationAcetylationBlood ProteinsChitinChitosanHumansMolecular WeightOligosaccharidesSerum Albumin, HumanBlood ProteinsChitinChitosanoligochitosanOligosaccharidesSerum Albumin, Humanchito-oligosaccharideshuman serum albuminα-1-glycoprotein

Identifiers

PMID33668290
PMCPMC7996291
OpenAlexW3130773630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.