ArticlePolymers2021
Chitosan Nanocarrier Entrapping Hydrophilic Drugs as Advanced Polymeric System for Dual Pharmaceutical and Cosmeceutical Application: A Comprehensive Analysis Using Box-Behnken Design.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Phyto-capped CuO Nanoparticles with Enhanced Antimicrobial and Anticancer Efficacy Against MCF-7 Cell Line: A Green Nanotherapeutic Approach.Applied biochemistry and biotechnology · 2026Article
- Formulation, Characterization, and Optimization of Ascorbic Acid-Loaded Chitosan Nanoparticles: Investigating the Impact of pH and Ionic Crosslinking Parameters.AAPS PharmSciTech · 2026Article
- In vitro release kinetics and in vivo plasma exposure of green tea polyphenols and caffeine from iron oxide chitosan nanoparticles.Scientific reports · 2026Article
- Development and optimization of Moxifloxacin solid lipid nanoparticles via double emulsion organic solvent free technique applying Box-Behnken experimental design.Scientific reports · 2025Article
- Article
- Exploring the Ocular Absorption Pathway of Fasudil Hydrochloride towards Developing a Nanoparticulate Formulation with Improved Performance.Pharmaceutics · 2024Article
- Functionalized surface of PLGA nanoparticles in thermosensitive gel to enhance the efficacy of antibiotics against antibiotic resistant infections in endodontics: A randomized clinical trial.International journal of pharmaceutics: X · 2023Article
- Dual-effects of caffeinated hyalurosomes as a nano-cosmeceutical gel counteracting UV-induced skin ageing.International journal of pharmaceutics: X · 2023Article
- Effect of alpha-lipoic acid and caffeine-loaded chitosan nanoparticles on obesity and its complications in liver and kidney in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade.BMC complementary medicine and therapies · 2023Article
- Review
- Anti-Inflammatory Effect and Toxicological Profile of Pulp Residue from theGels (Basel, Switzerland) · 2023Article
- Red sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial design: cytotoxicity and cellular reactive oxygen species levels.Frontiers in pharmacology · 2023Article
- Synthesis of Polyhydroxyurethanes-Experimental Verification of the Box-Behnken Optimization Model.Polymers · 2022Article
- Novel Therapeutic Approach in PEGylated Chitosan Nanoparticles of Apigenin for the Treatment of Cancer via Oral Nanomedicine.Polymers · 2022Article
- Article
- Activity of Propolis Nanoparticles against HSV-2: Promising Approach to Inhibiting Infection and Replication.Molecules (Basel, Switzerland) · 2022Article
- Article
- Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Ability.Polymers · 2022Article
- Hybrid chitosan-lipid nanoparticles of green tea extract as natural anti-cellulite agent with superiorDrug delivery · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the present research is to propose chitosan as a nanocarrier for caffeine-a commonly used drug in combating cellulite. Being a hydrophilic drug, caffeine suffers from insufficient topical penetration upon application on the skin. Chitosan nanoparticles loaded with caffeine were prepared via the ionic gelation technique and optimized according to a Box-Behnken design. The effect of (A) chitosan concentration, (B) chitosan solution pH, and (C) chitosan to sodium tripolyphosphate mass ratio on (Y1) entrapment efficiency percent, (Y2) particle size, (Y3) polydispersity index, and (Y4) zeta potential were studied. Subsequently, the desired constraints on responses were applied, and validation of the optimization procedure was confirmed by the parameters exhibited by the optimal formulation. A caffeine entrapment efficiency percent of 17.25 ± 1.48%, a particle size of 173.03 ± 4.32 nm, a polydispersity index of 0.278 ± 0.01, and a surface charge of 41.7 ± 3.0 mV were attained. Microscopical evaluation using transmission electron microscope revealed a typical spherical nature of the nanoparticles arranged in a network with a further confirmation of the formation of particles in the nano range. The results proved the successful implementation of the Box-Behnken design for optimization of chitosan-based nanoparticles in the field of advanced polymeric systems for pharmaceutical and cosmeceutical applications.
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