ArticleInternational journal of molecular sciences2021
COMP and TSP-4: Functional Roles in Articular Cartilage and Relevance in Osteoarthritis.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 51 citations in OpenAlex.
- Omics Studies in Osteoarthritis: A Review of Molecular Mechanisms and Candidate Molecules.Biomolecules · 2026Review
- Osteoarthritis: Epidemiology, Diagnosis, and Treatment.MedComm · 2026Review
- Pathogenic Implications of the THY1/NF-κB Feedback Relationship in Osteoarthritis and Its Potential as a Therapeutic Target.Journal of inflammation research · 2026Article
- Tissue maturation and development of mechanical properties in hyaluronic acid bioink-based cartilaginous constructs.Frontiers in bioengineering and biotechnology · 2026Article
- Expression of thrombospondin-4 in the infrapatellar fat pad and synovial fluid - potential contribution to osteoarthritis pain.Arthritis research & therapy · 2025Article
- Protective effect of cartilage oligomeric matrix protein (COMP) on osteoarthritis-like chondrocytes based on the nuclear factor kappa B (NF-κB) pathway.Journal of molecular histology · 2025Article
- Immunomodulation Effects of Porcine Cartilage Acellularized Matrix (pCAM) for Osteoarthritis Treatment.Tissue engineering and regenerative medicine · 2025Article
- Mediating Role of the ANGPTL3/TFPI Protein Ratio in Regulating T-Cell Surface Glycoprotein CD5 Levels on Knee Osteoarthritis (KOA): A Mendelian Randomization Study.International journal of molecular sciences · 2025Article
- Gold Nanoparticles as a Tool to Detect Biomarkers in Osteoarthritis: New Insights.Indian journal of microbiology · 2025Article
- Multi-Omics Integration Identifies FGF1 as a Diagnostic Biomarker and RAS-MAPK-Driven Pathogenic Factor in Osteoarthritis.Journal of inflammation research · 2025Article
- The Role of Thrombospondins in Osteoarthritis: from Molecular Mechanisms to Therapeutic Potential.International journal of biological sciences · 2025Review
- Landscape of Histone Posttranslational Modifications in Osteoarthritis.Journal of inflammation research · 2025Review
- Chronic intermittent hypobaric hypoxia alleviates early-stage posttraumatic osteoarthritis via NF-κB/Nrf2 pathway in mice.Journal of orthopaedic surgery and research · 2024Article
- Interconnected Pathways: Exploring Inflammation, Pain, and Cognitive Decline in Osteoarthritis.International journal of molecular sciences · 2024Article
- Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy.iScience · 2024Article
- Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model.International journal of molecular sciences · 2024Article
- Adipocyte enhancer binding protein 1 knockdown alleviates osteoarthritis through inhibiting NF-κB signaling pathway-mediated inflammation and extracellular matrix degradation.Journal of cell communication and signaling · 2024Article
- Article
- Cartilage Oligomeric Matrix Protein in Osteoarthritis and Obesity-Do New Considerations Emerge?International journal of molecular sciences · 2024Article
- Identification of diagnostic biomarkers for osteoarthritis through bioinformatics and machine learning.Heliyon · 2024Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Osteoarthritis (OA) is a slow-progressing joint disease, leading to the degradation and remodeling of the cartilage extracellular matrix (ECM). The usually quiescent chondrocytes become reactivated and accumulate in cell clusters, become hypertrophic, and intensively produce not only degrading enzymes, but also ECM proteins, like the cartilage oligomeric matrix protein (COMP) and thrombospondin-4 (TSP-4). To date, the functional roles of these newly synthesized proteins in articular cartilage are still elusive. Therefore, we analyzed the involvement of both proteins in OA specific processes in in vitro studies, using porcine chondrocytes, isolated from femoral condyles. The effect of COMP and TSP-4 on chondrocyte migration was investigated in transwell assays and their potential to modulate the chondrocyte phenotype, protein synthesis and matrix formation by immunofluorescence staining and immunoblot. Our results demonstrate that COMP could attract chondrocytes and may contribute to a repopulation of damaged cartilage areas, while TSP-4 did not affect this process. In contrast, both proteins similarly promoted the synthesis and matrix formation of collagen II, IX, XII and proteoglycans, but inhibited that of collagen I and X, resulting in a stabilized chondrocyte phenotype. These data suggest that COMP and TSP-4 activate mechanisms to protect and repair the ECM in articular cartilage.
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