ArticleMolecules (Basel, Switzerland)2021
A Tuneable, Photocurable, Poly(Caprolactone)-Based Resin for Tissue Engineering-Synthesis, Characterisation and Use in Stereolithography.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Bioactive 3D-Printed valve scaffold promoting valvular regeneration via immunomodulation and endothelialization.Bioactive materials · 2026Article
- Article
- Light-Based 3D Printing of Polyesters: From Synthesis to Fabrication.Chemical reviews · 2026Review
- Comparative evaluation of mechanical and physical properties of provisional crown and bridge materials fabricated using milling, three-dimensional printing and conventional methods: An in vitro study.Journal of Indian Prosthodontic Society · 2026Article
- Emulsion templating of PCL:PGS methacrylate blends for soft tissue engineering.Frontiers in bioengineering and biotechnology · 2026Article
- Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo.Scientific reports · 2024Article
- A Novel Poly(ε-Caprolactone)-Based Photo-Crosslinkable Liquid Copolymer as a Versatile Drug Delivery Platform.Pharmaceutics · 2024Article
- Ultra-Long-Term Delivery of Hydrophilic Drugs Using InjectablebioRxiv : the preprint server for biology · 2024Article
- Optimization of a High Internal Phase Emulsion-Based Resin for Use in Commercial Vat Photopolymerization Additive Manufacturing.3D printing and additive manufacturing · 2024Article
- Advanced Bioresin Formulation for 3D-Printed Bone Scaffolds: PCLDMA and p-PLA Integration.Polymers · 2024Article
- Surfactant-free gelatin-stabilised biodegradable polymerised high internal phase emulsions with macroporous structures.Frontiers in chemistry · 2023Article
- Long-Term Antibody Release Polycaprolactone Capsule and the Release Kinetics in Natural and Accelerated Degradation.ACS biomaterials science & engineering · 2022Article
- Developments and Clinical Applications of Biomimetic Tissue Regeneration using 3D Bioprinting Technique.Applied bionics and biomechanics · 2022Review
- 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery.Pharmaceutics · 2021Article
- 3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications.Pharmaceutics · 2021Review
- 3D Printing Polymer-based Bolus Used for Radiotherapy.International journal of bioprinting · 2021Review
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Authors and funding
4 authors.
Funding
Abstract
Stereolithography is a useful additive manufacturing technique for the production of scaffolds for tissue engineering. Here we present a tuneable, easy-to-manufacture, photocurable resin for use in stereolithography, based on the widely used biomaterial, poly(caprolactone) (PCL). PCL triol was methacrylated to varying degrees and mixed with photoinitiator to produce a photocurable prepolymer resin, which cured under UV light to produce a cytocompatible material. This study demonstrates that poly(caprolactone) methacrylate (PCLMA) can be produced with a range of mechanical properties and degradation rates. By increasing the degree of methacrylation (DM) of the prepolymer, the Young's modulus of the crosslinked PCLMA could be varied from 0.12-3.51 MPa. The accelerated degradation rate was also reduced from complete degradation in 17 days to non-significant degradation in 21 days. The additive manufacturing capabilities of the resin were demonstrated by the production of a variety of different 3D structures using micro-stereolithography. Here, β-carotene was used as a novel, cytocompatible photoabsorber and enabled the production of complex geometries by giving control over cure depth. The PCLMA presented here offers an attractive, tuneable biomaterial for the production of tissue engineering scaffolds for a wide range of applications.
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Registered trials
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