Evidence map›Paper›PMID 33668058›Full record

Trial reportThe American journal of clinical nutrition2021

Effects of dietary macronutrients on serum urate: results from the OmniHeart trial.

Matthew J Belanger, Christina C Wee, Kenneth J Mukamal, Edgar R Miller, Frank M Sacks, Lawrence J Appel, Robert H Shmerling, Hyon K Choi, Stephen P Juraschek

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00051350 (Macronutrients and Cardiovascular Risk), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00051350 nacompletednot on this map

Macronutrients and Cardiovascular Risk

TypeinterventionalSponsorJohns Hopkins UniversityRan2002 to 2008Enrolled164ConditionsCardiovascular Diseases, Heart Diseases, Atherosclerosis, HypertensionArmsCARB
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Role of diet in hyperuricemia and gout.Best practice & research. Clinical rheumatology · 2021
    Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Matthew J BelangerDivision of General Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
Christina C WeeDivision of General Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
Kenneth J MukamalDivision of General Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
Edgar R MillerDepartment of Medicine, Division of General Internal Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Frank M SacksDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Lawrence J AppelDepartment of Medicine, Division of General Internal Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0673-6823
Robert H ShmerlingDivision of Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
Hyon K ChoiDepartment of Medicine, Division of Rheumatology, Massachusetts General Hospital, Boston, MA, USA.
Stephen P JuraschekDivision of General Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
Beth Israel Deaconess Medical Center · USJohns Hopkins University · USHarvard University · USMassachusetts General Hospital · US

Funding

Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3M
The Effects of Urate Lowering Therapy on Inflammation, Endothelial function, andP50AR060772 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2012 to 2021
$12.8M
NOVEL METABOLITE AND MICROBIOTA PATHWAYS FOR HYPERURICEMIA AND GOUTR01AR065944 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI CHOI, HYON K · 2013 to 2025
$4.2M
Vitamin D, Subclinical Cardiovascular Disease, and Orthostatic Hypotension in Older AdultsK23HL135273 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2017 to 2021
$1.1M
The Effects of the DASH Diet and Sodium Reduction on Subclinical Cardiac DamageR21HL144876 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2018 to 2019
$263k
NHLBI NIH HHS K23 HL135273NHLBI NIH HHS R21 HL144876NIAMS NIH HHS P50 AR060772NIAMS NIH HHS R01 AR065944NIDDK NIH HHS P30 DK072488
6 · The paper itself

Abstract

backgroundDietary recommendations to prevent gout emphasize a low-purine diet. Recent evidence suggests that the Dietary Approaches to Stop Hypertension (DASH) diet reduces serum urate while also improving blood pressure and lipids.

objectiveTo compare the effects of DASH-style diets emphasizing different macronutrient proportions on serum urate reduction.

methodsWe conducted a secondary analysis of the Optimal Macronutrient Intake Trial to Prevent Heart Disease feeding study, a 3-period, crossover design, randomized trial of adults with prehypertension or hypertension. Participants were provided with 3 DASH-style diets in random order, each for 6 wk. Each DASH-style diet emphasized different macronutrient proportions: a carbohydrate-rich (CARB) diet, a protein-rich (PROT) diet, and an unsaturated fat-rich (UNSAT) diet. In the PROT diet, approximately half of the protein came from plant sources. We compared the effects of these diets on serum urate at weeks 4 and 6 of each feeding period.

resultsOf the 163 individuals included in the final analysis, the mean serum urate at baseline was 5.1 mg/dL. Only the PROT diet reduced serum urate from baseline at the end of the 6-wk feeding period (-0.16 mg/dL; 95% CI: -0.28, -0.04; P = 0.007). Neither the CARB diet (-0.03 mg/dL; 95% CI: -0.14, 0.09; P = 0.66) nor the UNSAT diet (-0.01 mg/dL; 95% CI: -0.12, 0.09; P = 0.78) reduced serum urate from baseline. The PROT diet lowered serum urate by 0.12 mg/dL (95% CI: -0.20, -0.03; P = 0.006) compared with CARB and by 0.12 mg/dL (95% CI: -0.20, -0.05; P = 0.002) compared with UNSAT.

conclusionsA DASH-style diet emphasizing plant-based protein lowered serum urate compared with those emphasizing carbohydrates or unsaturated fat. Future trials should test the ability of a DASH-style diet emphasizing plant-based protein to lower serum urate and prevent gout flares in patients with gout. This trial was registered at clinicaltrials.gov as NCT00051350.

Indexed as

DietDietary Approaches To Stop HypertensionNutrientsAdultCross-Over StudiesFemaleHumansMaleMiddle AgedUric AcidNutrientsUric Aciddietgouthypertensionlipidsmacronutrientproteinpurine

Identifiers

PMID33668058
PMCPMC8168362
OpenAlexW3133949420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.