Evidence map›Paper›PMID 33667601›Full record

ReviewNeuroscience letters2021

Mini review: Neural mechanisms underlying airway hyperresponsiveness.

Alexandra B Pincus, Allison D Fryer, David B Jacoby

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Heavy moms, wheezy kids: how maternal obesity harms breathing in offspring.American journal of respiratory cell and molecular biology · 2026
    Review
  3. Article
  4. Review
  5. Cracking the Code of the Jugular Vagal Sensory Neurons in Allergic Airway Responsiveness.American journal of respiratory cell and molecular biology · 2025
    Article
  6. Article
  7. Review
  8. Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  9. Article
  10. Neonatal rhinorrhea, heart rate variability, and childhood exercise-induced wheeze.The journal of allergy and clinical immunology. Global · 2023
    Article
  11. The ABCs and DEGs (Differentially Expressed Genes) of Airway Hyperresponsiveness.American journal of respiratory and critical care medicine · 2023
    Article
  12. Vagal Reflexes in Airway Hyperreactivity: Novel Pathways and a Note of Caution for Studies in Mice.American journal of respiratory cell and molecular biology · 2023
    Article
  13. Spinal Cord Injury Impairs Lung Immunity in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexandra B PincusOregon Health and Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA. Electronic address: pincus@ohsu.edu.
Allison D FryerOregon Health and Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
David B JacobyOregon Health and Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
Oregon Health & Science University · US

Funding

Prenatal control of offspring airway responsivenessR01HL144008 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOBY, DAVID B · 2019 to 2022
$2.4M
Insulin Modulates Parasympathetic Nerve Control of LungsR01HL131525 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI FRYER, ALLISON DEBORAH · 2017 to 2020
$1.9M
An optogenetic approach to airway researchR21AI152498 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOBY, DAVID B · 2020 to 2021
$424k
Airway sensory nerve changes in a mouse model of maternal allergen exposureF30HL145906 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI PINCUS, ALEXANDRA BOWMAN · 2019 to 2022
$200k
NHLBI NIH HHS F30 HL145906NHLBI NIH HHS R01 HL131525NHLBI NIH HHS R01 HL144008NIAID NIH HHS R21 AI152498
6 · The paper itself

Abstract

Neural changes underly hyperresponsiveness in asthma and other airway diseases. Afferent sensory nerves, nerves within the brainstem, and efferent parasympathetic nerves all contribute to airway hyperresponsiveness. Inflammation plays a critical role in these nerve changes. Chronic inflammation and pre-natal exposures lead to increased airway innervation and structural changes. Acute inflammation leads to shifts in neurotransmitter expression of afferent nerves and dysfunction of M

Indexed as

AnimalsAsthmaHumansNeurons, AfferentOptogeneticsParasympathetic Nervous SystemReceptors, MuscarinicSignal TransductionReceptors, MuscarinicAsthmaInflammationMuscarinicParasympatheticSensory

Identifiers

PMID33667601
PMCPMC8068501
OpenAlexW3134141437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.