ArticleThe Journal of biological chemistry
Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice.
Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Peel of Pomegranate Fruit (Current issues in molecular biology · 2026Article
- Twelve weeks of voluntary wheel running restores glucagon sensitivity in middle-aged mice.American journal of physiology. Endocrinology and metabolism · 2026Article
- Sinapine Modulates Glycogen and Lipid Synthesis via IRS1-PI3K-AKT-GSK3β-GS Pathway in Insulin-Resistant Models.Food science & nutrition · 2026Article
- The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice.NPJ science of food · 2025Article
- Hypoglycemic and hypolipidemic effect of pentaamino acid fullerene CJournal of bioenergetics and biomembranes · 2023Article
- Phloretamide Prevent Hepatic and Pancreatic Damage in Diabetic Male Rats by Modulating Nrf2 and NF-κB.Nutrients · 2023Article
- Active Glycogen Synthase in the Liver Prevents High-Fat Diet-Induced Glucose Intolerance, Decreases Food Intake, and Lowers Body Weight.International journal of molecular sciences · 2023Article
- Protein Targeting to Glycogen (PTG): A Promising Player in Glucose and Lipid Metabolism.Biomolecules · 2022Review
- Combined treatment with niclosamide ethanolamine and artemether combination improves type 1 diabetes via the targeting of liver mitochondria.Experimental and therapeutic medicine · 2022Article
- Hepatic overexpression of protein targeting to glycogen attenuates obesity and improves hyperglycemia in db/db mice.Frontiers in endocrinology · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic glycogen metabolism is impaired in diabetes. We previously demonstrated that strategies to increase liver glycogen content in a high-fat-diet mouse model of obesity and insulin resistance led to a reduction in food intake and ameliorated obesity and glucose tolerance. These effects were accompanied by a decrease in insulin levels, but whether this decrease contributed to the phenotype observed in this animal was unclear. Here we sought to evaluate this aspect directly, by examining the long-term effects of increasing liver glycogen in an animal model of insulin-deficient and monogenic diabetes, namely the Akita mouse, which is characterized by reduced insulin production. We crossed Akita mice with animals overexpressing protein targeting to glycogen (PTG) in the liver to generate Akita mice with increased liver glycogen content (Akita-PTG
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.