ArticleThe American journal of cardiology2021
Frailty and Post-hospitalization Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.
Article in The American journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Impact of frailty on outcomes in atrial fibrillation and HFpEF: data from the TOPCAT trial.BMC cardiovascular disorders · 2026Trial
- Neighborhood-Level Socially Determined Vulnerabilities and Outcomes After Heart Failure Hospitalization.Journal of the American Heart Association · 2026Article
- Fried Frailty Phenotype and 6-Month Risk of First All-Cause Rehospitalisation Among Older Outpatients with Heart Failure and LVEF >40%: A Multicentre Prospective Cohort Study.International journal of general medicine · 2026Article
- Comparison of Physical Frailty Assessments in Heart Failure With Preserved Ejection Fraction.JACC. Advances · 2024Article
- Telehealth-aided outpatient management of acute heart failure in a specialist virtual ward compared with standard care.ESC heart failure · 2024Article
- Heart Failure With Preserved Ejection Fraction and Frailty: From Young to Superaged Coexisting HFpEF and Frailty.International journal of heart failure · 2024Review
- Reducing heart failure deaths by 25% in 25 years: the '25in25' heart failure summit.The British journal of cardiology · 2024Article
- Malnutrition in heart failure with preserved ejection fraction.Journal of the American Geriatrics Society · 2023Article
- Development and validation of dynamic nomogram of frailty risk for older patients hospitalized with heart failure.International journal of nursing sciences · 2023Article
- Prevalence and prognosis of frailty in older patients with stage B heart failure with preserved ejection fraction.ESC heart failure · 2023Article
- Geriatric Domains in Patients with Heart Failure with Preserved Ejection Fraction.Cardiology clinics · 2022Review
- Analysis of Functional Recovery in Older Adults Discharged to Skilled Nursing Facilities and Then Home.JAMA network open · 2022Article
- Machine Learning Approaches for the Frailty Screening: A Narrative Review.International journal of environmental research and public health · 2022Review
- A visualization analysis of hotspots and frontiers of cardiovascular diseases with frailty.Frontiers in public health · 2022Article
- Association between frailty and short- and long-term mortality in patients with critical acute myocardial infarction: Results from MIMIC-IV.Frontiers in cardiovascular medicine · 2022Article
- Characteristics of patients with heart failure with preserved ejection fraction in primary care: a cross-sectional analysis.BJGP open · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
Given the role of comorbid conditions in the pathophysiology of HFpEF, we aimed to identify and rank the importance of comorbid conditions associated with post-hospitalization outcomes of older adults hospitalized for HFpEF. We examined data from 4,605 Medicare beneficiaries hospitalized in 2007-2014 for HFpEF based on ICD-9-CM codes for acute diastolic heart failure (428.31 or 428.33). To identify characteristics with high importance for prediction of mortality, all-cause rehospitalization, rehospitalization for heart failure, and composite outcome of mortality or all-cause rehospitalization up to 1 year, we developed boosted decision tree ensembles for each outcome, separately. For interpretability, we estimated hazard ratios (HRs) and 95% confidence intervals (CI) using Cox proportional hazards models. Age and frailty were the most important characteristics for prediction of mortality. Frailty was the most important characteristic for prediction of rehospitalization, rehospitalization for heart failure, and the composite outcome of mortality or all-cause rehospitalization. In Cox proportional hazards models, a 1-SD higher frailty score (0.1 on theoretical range of 0 to 1) was associated with a HR of 1.27 (1.06 to 1.52) for mortality, 1.16 (1.07 to 1.25) for all-cause rehospitalization, 1.24 (1.14 to 1.35) for HF rehospitalization, and 1.15 (1.07 to 1.25) for the composite outcome of mortality or all-cause rehospitalization. In conclusion, frailty is an important predictor of mortality and rehospitalization in adults aged ≥66 years with HFpEF.
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