Evidence map›Paper›PMID 33667355›Full record

ArticleCell stem cell2021

A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis.

Pierre A Coulombe, Sara A Wickström

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Pierre A CoulombeDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: coulombe@umich.edu.
Sara A WickströmStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Finland; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Finland.
University of Helsinki · FIUniversity of Michigan · US

Funding

Non-Canonical Functions of Keratin Proteins in SkinR01AR044232 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COULOMBE, PIERRE · 1996 to 2020
$8.6M
Role of keratin intermediate filaments in skin epithelial differentiation.R01AR079418 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COULOMBE, PIERRE · 2021 to 2025
$2.1M
NIAMS NIH HHS R01 AR044232NIAMS NIH HHS R01 AR079418
6 · The paper itself

Abstract

In this issue of Cell Stem Cell, Ning et al. (2021) demonstrate that contractility in differentiating, suprabasally located keratinocytes acts non-cell-autonomously to regulate the replication and differentiation of the stem/progenitor keratinocytes in the basal layer of epidermis. This finding expands our understanding of the niche that regulates stem/progenitor cells in skin.

Indexed as

EpigenomicsTranscription FactorsAnimalsCell DifferentiationEpidermal CellsEpidermisKeratinocytesStem CellsTranscription Factors

Identifiers

PMID33667355
PMCPMC9359084
OpenAlexW3134492901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.