Evidence map›Paper›PMID 33667353›Full record

ArticleCell stem cell2021

Stabilizing Formative Pluripotent States with Germ Cell Competency.

Ng Shyh-Chang, Lei Li

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The many dimensions of germline competence.Current opinion in cell biology · 2023
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ng Shyh-ChangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Beijing Institute of Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China. Electronic address: huangsq@ioz.ac.cn.
Lei LiState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Beijing Institute of Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China. Electronic address: lil@ioz.ac.cn.

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Previous work demonstrating the existence of intermediate pluripotency states in post-implantation embryos had ignited a debate on whether "formative" pluripotency can be stabilized in pluripotent stem cell (PSC) lines. In this issue of Cell Stem Cell, two papers show that polarized epithelial and germ cell-competent formative PSCs can be maintained in modified activin-dependent conditions.

Indexed as

Pluripotent Stem CellsActivinsAnimalsEmbryonic DevelopmentGerm CellsHumansMiceActivins

Identifiers

PMID33667353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.