SynthesisPloS one2021
Primary vitrectomy for degenerative and tractional lamellar macular holes: A systematic review and meta-analysis.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Surgical interventions for lamellar macular holes.The Cochrane database of systematic reviews · 2021Pooled it
- Distinct postoperative anatomical outcomes between lamellar macular holes and epiretinal membrane foveoschisis.Eye (London, England) · 2026Article
- Extended follow-up of ultrastructural remodeling and functional recovery after lamellar macular hole surgery using autologous platelet-rich plasma.Scientific reports · 2026Article
- EPIRETINAL PROLIFERATION EMBEDDING WITHOUT INTERNAL LIMITING MEMBRANE PEELING FOR LAMELLAR MACULAR HOLE.Retina (Philadelphia, Pa.) · 2026Article
- Combined versus Sequential Surgery in Lamellar Macular Holes: A Multicenter Observational Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Changes in visual acuity and retinal microstructures following vitrectomy for lamellar macular hole.PloS one · 2026Article
- Long-term optical coherence tomography changes and visual outcomes after vitrectomy for epiretinal proliferation: lamellar holes and full-thickness macular holes.International journal of retina and vitreous · 2025Article
- The no-retina-touch technique: vitrectomy and platelet-rich plasma in the treatment of lamellar macular hole. New insights into pathogenesis.Eye (London, England) · 2025Article
- Anatomic and Functional Outcomes of Lamellar Macular Hole and Epiretinal Membrane Foveoschisis Surgery: Predictive Factors and Associated Complications - A Retrospective Interventional Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Long-Term Results of Pars Plana Vitrectomy with Internal Limiting Membrane Peeling for Vitreomacular Traction Syndrome: A Prospective Investigation in Central Asian Population.Healthcare (Basel, Switzerland) · 2024Article
- Functional and Anatomical Outcomes of Pars Plana Vitrectomy for Lamellar Macular Hole: Long-Term Follow-Up.Diagnostics (Basel, Switzerland) · 2024Article
- Vitrectomy in Small idiopathic MAcuLar hoLe (SMALL) study: conventional internal limiting membrane peeling versus inverted flap.Eye (London, England) · 2024Article
- Epiretinal membrane: an overview and update.Japanese journal of ophthalmology · 2024Review
- Volumetric Biomarkers of Visual Outcome after Surgical Repair in Lamellar Macular Holes.Journal of personalized medicine · 2024Article
- Long-Term Results of Adjunct Autologous Platelet-Rich Plasma in Lamellar Macular Hole Surgery Showing Lasting Restoration of Foveal Anatomy.International journal of molecular sciences · 2023Article
- Lamellar macular defects: are degenerative lamellar macular holes truly degenerative?Frontiers in medicine · 2023Article
- Primary Lamellar Macular Holes: To Vit or Not to Vit.Journal of clinical medicine · 2022Review
- Improving morphological outcome in lamellar macular hole surgery by using highly concentrated autologous platelet-rich plasma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Macular Holes: Main Clinical Presentations, Diagnosis, and Therapies.Journal of ophthalmology · 2022Review
- Morphological Changes in Lamellar Macular Holes According to SD-OCT Examination over a Long Observation Period.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the efficacy of vitrectomy in degenerative and tractional lamellar macular holes (LMHs) by meta-analysis of published studies.
methodsPubMed, Medline and Embase databases were searched up to May 2020. Included cohorts were divided into three groups: degenerative LMH group, lamellar hole associated epiretinal proliferation (LHEP) group and tractional LMH group. LHEP is likely to be associated with degenerative LMHs, but less commonly could be associated with mixed LMHs. To reduce risk of possible misclassification bias, eyes with LHEP which could not have been precisely classified by the authors, were included into the LHEP group. The primary outcome was to investigate the visual change following primary vitrectomy in the degenerative LMH and LHEP group versus the tractional LMH group. A sensitivity analysis excluding the LHEP group was also performed on the primary outcome. Mean difference (MD) in best corrected visual acuity between baseline and post-treatment was calculated, along with 95% confidence interval (CI). Rate of incidence of post-operative full-thickness macular hole (FTMH) was assessed as secondary outcome.
resultsThirteen studies were included. Pooled analyses including all groups showed a significant visual improvement following vitrectomy (pre-post MD = -0.17;95%CI = -0.22,-0.12;p<0.001), with no difference in visual improvement between the degenerative LMH and LHEP group and the tractional LMH group. The sensitivity analysis excluding LHEP group confirmed no difference in visual change between the degenerative LMH group (pre-post MD = -0.18;95%CI = -0.24,-0.12;p<0.001) and the tractional LMH group (MD = -0.16;95%CI = -0.26,-0.07;p<0.001). The incidence rate of post-operative FTMH was higher in the degenerative LMH and LHEP group than in the tractional LMH group (p = 0.002).
conclusionPrimary vitrectomy for LMH ensured a favorable visual outcome, with no difference in visual gain between degenerative and tractional LMHs. However, a higher incidence of post-operative FTMHs was found in eyes with the degenerative LMH subtype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.