Evidence map›Paper›PMID 33667173›Full record

ArticleJMIR public health and surveillance2021

Community and Campus COVID-19 Risk Uncertainty Under University Reopening Scenarios: Model-Based Analysis.

James Benneyan, Christopher Gehrke, Iulian Ilies, Nicole Nehls

Abstract read
In one paragraph

Article in JMIR public health and surveillance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Use of Expert Elicitation among Computational Modeling Studies in Health Research: A Systematic Review.Medical decision making : an international journal of the Society for Medical Decision Making · 2022
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

James BenneyanHealthcare Systems Engineering Institute, Northeastern University, Boston, MA, United States.ORCID 0000-0003-0070-9709
Christopher GehrkeHealthcare Systems Engineering Institute, Northeastern University, Boston, MA, United States.ORCID 0000-0003-3809-2994
Iulian IliesHealthcare Systems Engineering Institute, Northeastern University, Boston, MA, United States.ORCID 0000-0002-2727-324X
Nicole NehlsHealthcare Systems Engineering Institute, Northeastern University, Boston, MA, United States.ORCID 0000-0002-4078-6082

Funding

Model-Informed Understanding and Mitigation of the U.S. Opioid and Heroin EpidemicR21DA046776 · NIDA · NORTHEASTERN UNIVERSITY · PI BENNEYAN, JAMES C · 2018 to 2019
$432k
NIDA NIH HHS R21 DA046776
6 · The paper itself

Abstract

backgroundSignificant uncertainty has existed about the safety of reopening college and university campuses before the COVID-19 pandemic is better controlled. Moreover, little is known about the effects that on-campus students may have on local higher-risk communities.

objectiveWe aimed to estimate the range of potential community and campus COVID-19 exposures, infections, and mortality under various university reopening plans and uncertainties.

methodsWe developed campus-only, community-only, and campus × community epidemic differential equations and agent-based models, with inputs estimated via published and grey literature, expert opinion, and parameter search algorithms. Campus opening plans (spanning fully open, hybrid, and fully virtual approaches) were identified from websites and publications. Additional student and community exposures, infections, and mortality over 16-week semesters were estimated under each scenario, with 10% trimmed medians, standard deviations, and probability intervals computed to omit extreme outliers. Sensitivity analyses were conducted to inform potential effective interventions.

resultsPredicted 16-week campus and additional community exposures, infections, and mortality for the base case with no precautions (or negligible compliance) varied significantly from their medians (4- to 10-fold). Over 5% of on-campus students were infected after a mean of 76 (SD 17) days, with the greatest increase (first inflection point) occurring on average on day 84 (SD 10.2 days) of the semester and with total additional community exposures, infections, and mortality ranging from 1-187, 13-820, and 1-21 per 10,000 residents, respectively. Reopening precautions reduced infections by 24%-26% and mortality by 36%-50% in both populations. Beyond campus and community reproductive numbers, sensitivity analysis indicated no dominant factors that interventions could primarily target to reduce the magnitude and variability in outcomes, suggesting the importance of comprehensive public health measures and surveillance.

conclusionsCommunity and campus COVID-19 exposures, infections, and mortality resulting from reopening campuses are highly unpredictable regardless of precautions. Public health implications include the need for effective surveillance and flexible campus operations.

Indexed as

Community-Acquired InfectionsCOVID-19HumansModels, TheoreticalRisk AssessmentUncertaintyUnited StatesUniversitiescommunitycommunity impactCOVID-19epidemic modelinfectious diseasemodelrisksafetystrategyuniversityuniversity reopening

Identifiers

PMID33667173
PMCPMC8030657

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.